| Gene Symbol | CDC27 |
|---|---|
| Entrez Gene | 996 |
| Alt Symbol | ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, H-NUC, HNUC, NUC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 27 |
| Other Description | anaphase promoting complex subunit 3|anaphase-promoting complex, protein 3|cell division cycle 27 homolog|cell division cycle protein 27 homolog|nuc2 homolog |
| Swissprots | Q96F35 G3V1C4 Q16349 P30260 |
| Accessions | AAR89911 AFI24904 AFI24906 AFI24908 EAW57686 EAW57687 EAW57688 EAW57689 P30260 AA927469 AK296881 BAG59442 AK299342 BAG61343 AU135593 BC011656 AAH11656 BI548077 BP234964 DQ786193 DQ892780 ABM83706 DQ896027 ABM87026 HY023336 S78234 AAB34378 U00001 AAA60471 XM_011525546 XP_011523848 XM_011525547 XP_011523849 XM_011525548 XP_011523850 XM_011525549 XP_011523851 XM_011525550 XP_011523852 XR_934630 NM_001114091 NP_001107563 NM_001256 NP_001247 NM_001293089 NP_001280018 NM_001293091 NP_001280020 |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |