| Gene Symbol |
GPA1
|
| Entrez Gene |
856394
|
| Alt Symbol |
CDC70, DAC1, SCG1
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide-binding protein subunit alpha
|
| Other Description |
-
|
| Swissprots |
D3DKU8 P08539
|
| Accessions |
DAA06692 P08539 NM_001179135 NP_011868
|
| Function |
Alpha subunit of the heterotrimeric guanine nucleotide- binding protein (G protein) that mediates mating pheromone signal transduction. Binding of alpha-factor or a-factor to its cognate transmembrane receptor STE2 and STE3, respectively, allows the receptor to serve as a guanine nucleotide exchange factor (GEF) on GPA1. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit STE4, leading to dissociation of the G protein beta-gamma dimer STE4- STE18. The dissociated subunits activate downstream effectors to activate the mating response pathway and induce changes necessary to produce mating-competent cells. STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fu
|
| Subcellular Location |
Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Localizes predominantly to the plasma membrane in its inactive, GDP-bound form, and is directed to endosomes once in its active, GTP-bound form. Concentrates at the tip of the mating projections.
|
| Top Pathways |
MAPK signaling pathway - yeast
|