GPA1

Gene Symbol GPA1
Entrez Gene 856394
Alt Symbol CDC70, DAC1, SCG1
Species Yeast
Gene Type protein-coding
Description guanine nucleotide-binding protein subunit alpha
Other Description -
Swissprots D3DKU8 P08539
Accessions DAA06692 P08539 NM_001179135 NP_011868
Function Alpha subunit of the heterotrimeric guanine nucleotide- binding protein (G protein) that mediates mating pheromone signal transduction. Binding of alpha-factor or a-factor to its cognate transmembrane receptor STE2 and STE3, respectively, allows the receptor to serve as a guanine nucleotide exchange factor (GEF) on GPA1. The exchange of GDP for GTP on the G protein alpha subunit alters its interaction with the G protein beta subunit STE4, leading to dissociation of the G protein beta-gamma dimer STE4- STE18. The dissociated subunits activate downstream effectors to activate the mating response pathway and induce changes necessary to produce mating-competent cells. STE4-STE18 activate the downstream pheromone signaling MAP kinase cascade leading to expression of mating-specific genes, inducing cell cycle arrest in G1, promoting polarized cell growth to form mating projections (shmoos), and establishing the changes in plasma membrane, cell wall and nuclear envelope to permit cell-cell fu
Subcellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Localizes predominantly to the plasma membrane in its inactive, GDP-bound form, and is directed to endosomes once in its active, GTP-bound form. Concentrates at the tip of the mating projections.
Top Pathways MAPK signaling pathway - yeast

Recombinant Saccharomyces cerevisiae Guanine nucleotide-binding protein alpha-1 - CSB-YP362451SVG CSB-EP362451SVG CSB-BP362451SVG CSB-MP362451SVG from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Yeast

Guanine nucleotide-binding protein alpha-1 subunit (GPA1), Recombinant Protein - MBS1226092 from MyBioSource

Category Protein
Prices $1,255.00, $1,255.00, $1,475.00, $1,475.00, $2,045.00, $2,045.00, $2,510.00, $2,510.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Yeast
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