RAN

Gene Symbol RAN
Entrez Gene 5901
Alt Symbol ARA24, Gsp1, TC4
Species Human
Gene Type protein-coding
Description RAN, member RAS oncogene family
Other Description GTP-binding nuclear protein Ran|GTPase Ran|OK/SW-cl.81|RanGTPase|androgen receptor-associated protein 24|guanosine triphosphatase Ran|member RAS oncogene family|ras-like protein TC4|ras-related nuclear protein
Swissprots Q8NI90 A8K3Z8 Q6IPB2 P62826
Accessions AAB24940 EAW98515 EAW98516 EAW98517 P62826 AB062399 BAB93486 AF052578 AAC05840 AF054183 AAC99400 AF501887 AAM15923 AK300934 BAG62563 AK311223 AK312466 BAG35373 AK316193 BAH14564 AL357616 BC000852 BC004272 AAH04272 BC014518 AAH14518 BC014901 AAH14901 BC016654 AAH16654 BC022813 BC051908 AAH51908 BC072000 AAH72000 BT007271 AAP35935 CR450347 CAG29343 DQ892358 ABM83284 DQ895565 ABM86491 HY139187 HY336901 M31469 AAA36546 NM_001300796 NP_001287725 NM_001300797 NP_001287726 NM_006325 NP_006316
Function GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.
Tissue Specificity Expressed in a variety of tissues. {ECO:0000269|PubMed:2108320}.
Top Pathways RNA transport, Ribosome biogenesis in eukaryotes, HTLV-I infection, Epstein-Barr virus infection

Ran Antibody - 4462 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, C6, COS, BAEC, and CHO cells, using Ran Antibody.

Ran (A-7) - sc-271376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ran (A-7): sc-271376. Western blot analysis of Ran expression in HeLa whole cell lysate.

Ran (ARAN1) - sc-58467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ran (ARAN1): sc-58467. Western blot analysis of Ran expression in non-transfected: sc-117752 (A) and human Ran transfected: sc-113333 (B) 293T whole cell lysates.

Ran (H-96) - sc-20802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ran (H-96): sc-20802. Western blot analysis of Ran expression in phorbol-induced HeLa (A) and A-431 (B) nuclear extracts.

Ran (C-20) - sc-1156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ran (C-20): sc-1156. Western blot analysis of Ran expression in whole cell lysates (A,C,E) and nuclear extracts (B,D,F) of A-431 (A,B), HeLa (C,D) and Jurkat (E,F) cells.

Ran (N-19) - sc-1155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ran (N-19): sc-1155. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-Ran antibody - ab53775 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ran antibody (ab53775) at 1/500 dilutionLane 1 : Extracts from LOVO cellsLane 2 : Extracts from LOVO cells, plus immunising peptide

Anti-Ran antibody - ab4781 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Ran antibody - ab31118 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Human breast stained with ab31118 at a 1/50 dilution

Anti-Ran antibody [EPR10790(B)] - ab157213 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10790(B)
All lanes : Anti-Ran antibody [EPR10790(B)] (ab157213) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-Ran antibody [EPR10791(B)] - ab155103 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10791(B)
Overlay histogram showing HeLa cells stained with ab155103 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab155103, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Ran antibody, prediluted - ab31120 from Abcam

Prices $384.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human breast stained with ab31120 for 30 minutes at room temperature.

Anti-RAN Antibody (aa167-216) IHC-plus™ - LS-B7616 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RAN antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7616 concentration 20 ug/ml.

Anti-RAN Antibody - LS-C109538 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-RAN Antibody (aa2-14) IHC-plus™ - LS-B8294 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-RAN antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8294 dilution 3.75 ug/ml.

Anti-RAN Antibody (aa12-39) - LS-C162428 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with RAN Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-RAN Antibody - LS-C331176 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach cancer using RAN antibody at dilution of 1:200 (400x lens).

Anti-RAN Antibody - LS-C38721 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAN Antibody - LS-C38720 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAN Antibody (Arg28/Asn143) - LS-C93619 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RAN Antibody (C-Terminus) - LS-C93621 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-RAN Antibody - LS-C93622 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-RAN Antibody (aa197-216) - LS-C50353 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Human breast stained with Anti-Ran

Anti-RAN Antibody - LS-C82247 from LifeSpan Bioscience

Prices $380.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of RAN antibody LS-C82247.

Anti-RAN Antibody - LS-C136853 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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