GSN

Gene Symbol GSN
Entrez Gene 2934
Alt Symbol ADF, AGEL
Species Human
Gene Type protein-coding
Description gelsolin
Other Description actin-depolymerizing factor|brevin
Swissprots B7Z5V1 Q8WVV7 Q5T0I2 A8MUD1 B7Z373 F5H1A8 P06396 A8MYN7 A2A418
Accessions CAA30101 CAA30102 EAW87489 EAW87490 EAW87491 P06396 AI742454 AK092797 BAG52611 AK096280 BAG53247 AK125819 BAG54252 AK295201 BAH12010 AK295572 BAH12109 AK297870 BAH12682 AK299453 BAH13037 AK300631 BAH13318 AK304629 BAH14228 AK304675 BAH14236 AK307859 AK315494 BAG37878 AL832070 CAH10407 BC017491 AAH17491 BC026033 AAH26033 BU151663 BX647999 DA294394 DA394782 DA450851 DA823796 DB170452 DB250757 DC316173 DC341948 DC370937 DC378873 DQ892187 ABM83113 EU176693 ABW03494 X04412 CAA28000 XM_005251940 XP_005251997 XM_005251943 XP_005252000 XM_005251944 XP_005252001 XM_005251945 XP_005252002 XM_006717075 XP_006717138 XM_006717079 XP_006717142 XM_011518584 XP_011516886 XM_011518585 XP_011516887 XM_011518586 XP_011516888 XM_011518587 XP_011516889 XM_011518588 XP_011516890 XM_011518589 XP_011516891 XM_011518590 XP_011516892 XM_011518591 XP_011516893 XM_011518592 XP_011516894 XM_011518593 XP_011516895 XM_011518594 XP_011516896 NM_000177 NP_000168 NM_001127662 NP_001121134 NM_001127663 NP_001121135 NM_001127664 NP_001121136 NM_001127665 NP_001121137 NM_001127666 NP_001121138 NM_001127667 NP_001121139 NM_001258029 NP_001244958 NM_001258030 NP_001244959 NM_198252 NP_937895
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.
Subcellular Location Isoform 2: Cytoplasm, cytoskeleton.
Tissue Specificity Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Top Pathways Fc gamma R-mediated phagocytosis, Viral carcinogenesis, Regulation of actin cytoskeleton

Gelsolin (D9W8Y) Rabbit mAb - 12953 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9W8Y
Western blot analysis of extracts from various cell lines using Gelsolin (D9W8Y) Rabbit mAb.

Gelsolin Antibody - 8090 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Gelsolin (F-3) - sc-271001 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gelsolin (F-3): sc-271001. Western blot analysis of Gelsolin expression in Raji whole cell lysate.

Gelsolin (H-5) - sc-398244 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gelsolin (H-5): sc-398244. Western blot analysis of Gelsolin expression in T-47D (A) and HISM (B) whole cell lysates and human smooth muscle (C) and human uterus (D) tissue extracts.

Gelsolin (H-70) - sc-48769 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gelsolin (H-70): sc-48769. Western blot analysis of Gelsolin expression in BJAB whole cell lysate.

Gelsolin (C-20) - sc-6405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Gelsolin expression in BJAB whole cell lysates (A,B). Antibodies tested include Gelsolin (C-20): sc-6405 (A) and Gelsolin (N-18): sc-6406 (B).

Gelsolin (C-18) - sc-22602 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Gelsolin (C-18): sc-22602. Western blot analysis of Gelsolin expression in HISM (A) and T-47D (B) whole cell lysates and human uterus (C) and human smooth muscle (D) tissue extracts.

Gelsolin (N-18) - sc-6406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Gelsolin expression in BJAB whole cell lysates (A,B). Antibodies tested include Gelsolin (C-20): sc-6405 (A) and Gelsolin (N-18): sc-6406 (B).

Gelsolin (N-19) - sc-22600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Gelsolin (ABS 017) - sc-57509 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Gelsolin (ABS 017): sc-57509. Western blot analysis of Gelsolin expression in BJAB (A), Raji (B) and HISM (C) whole cell lysates.

Anti-Gelsolin antibody - ab74420 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Gelsolin antibody (ab74420) at 1 µg/mlLane 1 : Kidney (Rat) Tissue Lysate Lane 2 : Spleen (Mouse) Tissue Lysate Lane 3 : Thymus (Rat) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Gelsolin antibody - ab55070 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Gelsolin antibody (ab55070) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human adrenal gland.

Anti-Gelsolin antibody [EP1940Y] - ab134183 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1940Y
Anti-Gelsolin antibody [EP1940Y] (ab134183) at 1/5000 dilution + NIH3T3 cell lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Gelsolin antibody [EPR1941Y] - ab75832 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1941Y
Anti-Gelsolin antibody [EPR1941Y] (ab75832) at 1/50000 dilution + human plasma at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Gelsolin antibody [EPR1942] - ab109014 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1942
Overlay histogram showing HL60 cells stained with ab109014 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109014, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HL60 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Gelsolin antibody [GEL-42] - ab82267 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GEL-42
ab82267 staining Gelsolin in Human platelets by Flow Cytometry. Platelets were isolated form Platelet rich plasma and suspended in PBS, fixed with paraformaldehyde and permeabilized with 0.1% Triton-X100 in 2% BSA for 30 minutes. The sample was incubated with the primary antibody (1/200 in PBS + 2% BSA) for 18 hours at 4°C. An Alexa Fluor®594-conjugated Goat anti-mouse IgG polyclonal (1/500) was used as the secondary antibody. Gating Strategy: PlateletsSee Abreview

Anti-Gelsolin antibody - C-terminal - ab183095 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Gelsolin antibody - C-terminal (ab183095) at 1/1550 dilutionLane 1 : RAW264.7 cell lysateLane 2 : NIH3T3 cell lysateLysates/proteins at 30 µg per lane.SecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilutiondeveloped using the ECL technique

Anti-Gelsolin plasma antibody - ab136832 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Gelsolin plasma antibody (ab136832) at 1 µg/ml + Human duodenum lysate (in RIPA buffer) at 35 µgSecondaryHRP labelled rabbit anti-goat at 1/20000 dilutiondeveloped using the ECL technique

Anti-GSN / Gelsolin Antibody (C-Terminus, clone GS-2C4) - LS-C66455 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GS-2C4

Anti-GSN / Gelsolin Antibody - LS-C62030 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-GSN / Gelsolin Antibody - LS-C121852 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-GSN / Gelsolin Antibody - LS-C121853 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GSN / Gelsolin Antibody (aa1-782) - LS-C129230 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GSN / Gelsolin Antibody (aa729-742) - LS-C129231 from LifeSpan Bioscience

Prices $435.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-GSN / Gelsolin Antibody (aa615-626) - LS-C54907 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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