| Gene Symbol |
Lta
|
| Entrez Gene |
16992
|
| Alt Symbol |
LT, LT-[a], LT-alpha, LT[a], LTalpha, Ltx, TNF-beta, TNFSF1, Tnfb, Tnfsf1b, hlb382
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lymphotoxin A
|
| Other Description |
TNF beta|lymphotoxin alpha|lymphotoxin-alpha|tumor necrosis factor ligand superfamily member 1
|
| Swissprots |
P09225
|
| Accessions |
AAA18593 AAA39450 AAA40461 AAC82485 CAA29566 CAA29567 CAA68330 CAA68529 EDL26629 EDL26630 P09225 AK080308 BAC37874 AK153694 BAE32147 AK156659 BAE33797 BC099464 AAH99464 M16819 AAA40460 X14800 CAA32906 XM_006523731 XP_006523794 XM_006525331 XP_006525394 XM_006536550 XP_006536613 XM_006537284 XP_006537347 NM_010735 NP_034865
|
| Function |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
|
| Subcellular Location |
Secreted {ECO:0000250}. Membrane {ECO:0000250}. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. {ECO:0000250}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Type I diabetes mellitus, HTLV-I infection, Herpes simplex infection, TNF signaling pathway
|