CACNA1S

Gene Symbol CACNA1S
Entrez Gene 779
Alt Symbol CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, L type, alpha 1S subunit
Other Description calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis)|dihydropyridine receptor|dihydropyridine-sensitive L-type calcium channel alpha-1 subunit|voltage-dependent L-type calcium channel subunit alpha-1S|voltage-gated calcium channel subunit alpha Cav1.1
Swissprots Q13934 A4IF51 Q12896 B1ALM2 Q13698
Accessions AAB37235 EAW91333 EAW91334 EAW91335 Q13698 BC133671 AAI33672 L33798 AAA51902 U09784 AAA20531 U14413 AAC50397 U18986 AAC50398 XM_005245478 XP_005245535 NM_000069 NP_000060
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Skeletal muscle specific.
Top Pathways Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway

Human CACNA1S protein fragment - ab114520 from Abcam

Category Protein
Prices $420.00
Sizes 10 µg
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of CACNA1S protein (ab114520). Stained with Coomassie Blue.

CACNA1S Partial Recombinant Protein - H00000779-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

CACNA1S - H00000779-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CACNA1S - H00000779-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) - RPF235Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S) - RPF235Mu02 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

CACNA1S Recombinant Protein Antigen - NBP2-33799PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CACNA1S Protein - NBP2-33541PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

CACNA1S Peptide, Human - M34GP02261H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit (CACNa1S), Recombinant Protein - MBS2086894 from MyBioSource

Category Protein
Prices $160.00, $320.00, $495.00
Sizes 10 µg, 50 µg, 100 µg
Source E Coli
Species Human
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