CACNA1S

Gene Symbol CACNA1S
Entrez Gene 779
Alt Symbol CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, L type, alpha 1S subunit
Other Description calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis)|dihydropyridine receptor|dihydropyridine-sensitive L-type calcium channel alpha-1 subunit|voltage-dependent L-type calcium channel subunit alpha-1S|voltage-gated calcium channel subunit alpha Cav1.1
Swissprots Q13934 A4IF51 Q12896 B1ALM2 Q13698
Accessions AAB37235 EAW91333 EAW91334 EAW91335 Q13698 BC133671 AAI33672 L33798 AAA51902 U09784 AAA20531 U14413 AAC50397 U18986 AAC50398 XM_005245478 XP_005245535 NM_000069 NP_000060
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Skeletal muscle specific.
Top Pathways Alzheimer's disease, Arrhythmogenic right ventricular cardiomyopathy (ARVC), cAMP signaling pathway, MAPK signaling pathway, Calcium signaling pathway

L-type Ca ++ CP α1S (N-19) - sc-8160 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α 1S (N-19): sc-8160. Western blot analysis of L-type Ca<sup>++</sup> CP α 1S expression in mouse (A) and rat (B) skeletal muscle tissue extracts.

L-type Ca ++ CP α1S (IIF71VH3) - sc-21782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L-type Ca<sup>++</sup> CP α1S (IIF71VH3): sc-21782. Western blot analysis of L-type Ca<sup>++</sup> CP α1S expression in rabbit KCl-treated microsomes. Kindly provided by L. McDonough at University of Iowa.

L-type Ca ++ CP α1S (C-17) - sc-16257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

L-type Ca ++ CP α1S (IIC12D4) - sc-21781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
L-type Ca<sup>++</sup> CP α1S (IIC12D4): sc-21781. Western blot analysis of L-type Ca<sup>++</sup> CP α1S expression in rat skeletal muscle tissue extract.

L-type Ca ++ CP α1S (H-263) - sc-20814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
L-type Ca<sup>++</sup> CP α1S (H-263): sc-20814. Immuno?peroxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

L-type Ca ++ CP α1S (Y-18) - sc-16256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CACNA1S antibody - ab96413 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CACNA1S antibody (ab96413) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-CACNA1S antibody - ab203662 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat skeletal muscle tissue labeling CACNA1S with ab203662 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-CACNA1S antibody - ab106343 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA1S antibody [1A] - ab2862 from Abcam

Prices $370.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1A
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) was performed on normal biopsies of deparaffinized human skeletal muscle tissue. Heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes. Tissues were blocked in 3% BSA-PBS for 30 minutes at room temperature. Tissues were then incubated with ab2862 (1:20) or without primary antibody (negative control) overnight at 4°C in a humidified chamber. Tissues were washed extensively with PBST and endogenous peroxidase activity was quenched with a peroxidase suppressor. Detection was performed using a biotin-conjugated secondary antibody and SA-HRP, followed by colorimetric detection using DAB. Tissues were counterstained with hematoxylin and prepped for mounting.

Anti-CACNA1S antibody [mAB 1a] - ab78003 from Abcam

Host Mouse
Clonality Monoclonal
Clone mAB 1a

Anti-CACNA1S / Cav1.1 Antibody - LS-C22829 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CACNA1S / Cav1.1 Antibody - LS-C152942 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CACNA1S / Cav1.1 Antibody (clone 2C5) - LS-C196799 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C5
Detection limit for recombinant GST tagged CACNA1S is approximately 0.3 ng/ml as a capture antibody.

Anti-CACNA1S / Cav1.1 Antibody (aa544-885) - LS-C185510 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Cal27 xenograft using CACNA1S antibody at 1:100 dilution.

CACNA1S Antibody (1A) - NB300-542 from Novus Biologicals

Prices $299.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 1A
Immunohistochemistry-Paraffin: CACNA1S Antibody (1A) [NB300-542] - Immunohistochemistry was performed on normal biopsies of deparaffinized human skeletal muscle tissue.

CACNA1S Antibody - NBP2-33541 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33541] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

CACNA1S Antibody - NBP1-31659 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CACNA1S Antibody [NBP1-31659] - Sample (30 ug of whole cell lysate) A: 293T 5% SDS PAGE; antibody diluted at 1:1000.

CACNA1S Antibody (mAB 1a) - NBP2-29825 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone mAB 1a

CACNA1S Antibody - NBP1-30675 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CACNA1S Antibody - NBP2-33799 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CACNA1S Antibody [NBP2-33799] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.

CACNA1S Antibody (2C5) - H00000779-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C5
Sandwich ELISA: CACNA1S Antibody (2C5) [H00000779-M01] - Detection limit for recombinant GST tagged CACNA1S is approximately 0.3ng/ml as a capture antibody.

CACNA1S Antibody - H00000779-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

CACNA1S Polyclonal Antibody - bs-9925R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat skeletal muscle labeled with  Rabbit Anti CACNA1S Polyclonal Antibody, Unconjugated (bs-9925R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Monoclonal Anti-Dihydropyridine Receptor (α1 Subunit) antibody produced in mouse - D218 from Sigma-Aldrich

Prices $484.50
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A
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