| Gene Symbol |
CNOT8
|
| Entrez Gene |
9337
|
| Alt Symbol |
CAF1, CALIF, Caf1b, POP2, hCAF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 8
|
| Other Description |
CAF1-like protein|CAF2|CALIFp|CCR4-NOT transcription complex subunit 8|CCR4-associated factor 8|PGK promoter directed over production
|
| Swissprots |
B0AZS3 D3DQI8 B7Z8R1 Q9H6Y1 Q9UFF9 Q7Z521 O95709 B2RAR8
|
| Accessions |
EAW61625 EAW61626 EAW61627 EAW61628 Q9UFF9 AF053318 AAD02685 AF087844 AAP97157 AF180476 AAF29830 AK025358 BAB15119 AK297381 BAH12567 AK299589 BAH13076 AK303775 BAH14047 AK309359 AK314317 BAG36965 AK315864 BAF98755 AK316055 BAH14426 AK316221 BAH14592 AK316269 BAH14640 AL122045 CAB59181 AL520837 AM393646 CAL38522 BC017366 AAH17366 BC093025 BT006857 AAP35503 BX647124 DC387160 XM_005268527 XP_005268584 XM_011537706 XP_011536008 XM_011537707 XP_011536009 XM_011537708 XP_011536010 XM_011537709 XP_011536011 NM_001301073 NP_001288002 NM_001301074 NP_001288003 NM_001301075 NP_001288004 NM_001301077 NP_001288006 NM_001301080 NP_001288009 NM_001301082 NP_001288011 NM_001301083 NP_001288012 NM_001301086 NP_001288015 NM_004779 NP_004770
|
| Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12771185}. Nucleus {ECO:0000269|PubMed:12771185}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: CNOT8 Overexpression Lysate (Adult Normal) [NBL1-09321] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOT8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4765_CNOT8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09321-img0002.jpg)