CNOT8

Gene Symbol	CNOT8
Entrez Gene	9337
Alt Symbol	CAF1, CALIF, Caf1b, POP2, hCAF1
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 8
Other Description	CAF1-like protein|CAF2|CALIFp|CCR4-NOT transcription complex subunit 8|CCR4-associated factor 8|PGK promoter directed over production
Swissprots	B0AZS3 D3DQI8 B7Z8R1 Q9H6Y1 Q9UFF9 Q7Z521 O95709 B2RAR8
Accessions	EAW61625 EAW61626 EAW61627 EAW61628 Q9UFF9 AF053318 AAD02685 AF087844 AAP97157 AF180476 AAF29830 AK025358 BAB15119 AK297381 BAH12567 AK299589 BAH13076 AK303775 BAH14047 AK309359 AK314317 BAG36965 AK315864 BAF98755 AK316055 BAH14426 AK316221 BAH14592 AK316269 BAH14640 AL122045 CAB59181 AL520837 AM393646 CAL38522 BC017366 AAH17366 BC093025 BT006857 AAP35503 BX647124 DC387160 XM_005268527 XP_005268584 XM_011537706 XP_011536008 XM_011537707 XP_011536009 XM_011537708 XP_011536010 XM_011537709 XP_011536011 NM_001301073 NP_001288002 NM_001301074 NP_001288003 NM_001301075 NP_001288004 NM_001301077 NP_001288006 NM_001301080 NP_001288009 NM_001301082 NP_001288011 NM_001301083 NP_001288012 NM_001301086 NP_001288015 NM_004779 NP_004770
Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12771185}. Nucleus {ECO:0000269|PubMed:12771185}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CNOT8 full length protein - ab132852 from Abcam Category Protein Source Wheat germ Species Human

Human CNOT8 full length protein - ab167839 from Abcam Category Protein Source E. coli Species Human

Human CNOT8 peptide - ab101310 from Abcam Category Peptide

Human CNOT8 protein fragment - ab160438 from Abcam Category Protein Source Wheat germ Species Human

CNOT8 Antibody Blocking Peptide - LS-E2025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT8 Antibody Blocking Peptide - LS-E8258 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT8 Antibody Blocking Peptide - LS-E13846 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT8 Antibody Blocking Peptide - LS-E13847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT8 Recombinant Protein - H00009337-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

CNOT8 Partial Recombinant Protein - H00009337-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CNOT8 Protein - NBP2-22743 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

CNOT8-Antibody-N-term-Blocking-peptide - BP12889a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CNOT8-Antibody-C-term-Blocking-Peptide - BP6521b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CNOT8 protein - orb191225 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

CNOT8 protein (His tag) - 80R-2866 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

CNOT8 (1-292, His-tag) - AR50985PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

CNOT8 (1-292, His-tag) - AR50985PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

CNOT8 - H00009337-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CNOT8 - H00009337-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CNOT8 - H00009337-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CNOT8, 1-292aa, Human, His tag, E.coli - 01-P2161 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

CNOT8 fusion protein - ag1201 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human CCR4-NOT transcription complex, subunit 8, His-tagged - CNOT8-207H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CCR4-NOT transcription complex subunit 8(CNOT8) - CSB-YP871398HU CSB-EP871398HU CSB-BP871398HU CSB-MP871398HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CNOT8, 1-292aa, Human, His tag, E.coli - ATGP2161 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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