| Gene Symbol | MAP1LC3B |
|---|---|
| Entrez Gene | 81631 |
| Alt Symbol | ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a |
| Species | Human |
| Gene Type | protein-coding |
| Description | microtubule-associated protein 1 light chain 3 beta |
| Other Description | MAP1 light chain 3-like protein 2|MAP1A/MAP1B LC3 B|MAP1A/MAP1B light chain 3 B|autophagy-related ubiquitin-like modifier LC3 B|microtubule-associated proteins 1A/1B light chain 3B |
| Swissprots | Q6NW02 Q9GZQ8 |
| Accessions | EAW95392 EAW95393 EAW95394 EAW95395 EAW95396 EAW95397 EAW95398 EAW95399 Q9GZQ8 AF087871 AAM10499 AF183417 AAG09686 AF303888 AAG23182 AK024571 AK025556 BAB15169 AK290956 BAF83645 AK310224 AK310335 AL834298 CAD38970 AM393561 CAL38438 BC018634 AAH18634 BC041874 AAH41874 BC045759 AAH45759 BC048009 BC067797 AAH67797 BG771621 DA577457 DB055844 DQ893152 ABM84078 DQ896448 ABM87447 JN663879 AEZ06292 NM_022818 NP_073729 |
| Function | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. {ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}. |
| Tissue Specificity | Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. {ECO:0000269|PubMed:12740394}. |