MAP1LC3B

Gene Symbol	MAP1LC3B
Entrez Gene	81631
Alt Symbol	ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Species	Human
Gene Type	protein-coding
Description	microtubule-associated protein 1 light chain 3 beta
Other Description	MAP1 light chain 3-like protein 2|MAP1A/MAP1B LC3 B|MAP1A/MAP1B light chain 3 B|autophagy-related ubiquitin-like modifier LC3 B|microtubule-associated proteins 1A/1B light chain 3B
Swissprots	Q6NW02 Q9GZQ8
Accessions	EAW95392 EAW95393 EAW95394 EAW95395 EAW95396 EAW95397 EAW95398 EAW95399 Q9GZQ8 AF087871 AAM10499 AF183417 AAG09686 AF303888 AAG23182 AK024571 AK025556 BAB15169 AK290956 BAF83645 AK310224 AK310335 AL834298 CAD38970 AM393561 CAL38438 BC018634 AAH18634 BC041874 AAH41874 BC045759 AAH45759 BC048009 BC067797 AAH67797 BG771621 DA577457 DB055844 DQ893152 ABM84078 DQ896448 ABM87447 JN663879 AEZ06292 NM_022818 NP_073729
Function	Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. {ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205}.
Subcellular Location	Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.
Tissue Specificity	Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. {ECO:0000269|PubMed:12740394}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® LC3B siRNA I - 6212 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® LC3B siRNA II - 6213 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

MAP LC3β CRISPR/Cas9 KO Plasmid (h) - sc-417828 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β HDR Plasmid (h) - sc-417828-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β Double Nickase Plasmid (h) - sc-417828-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β Double Nickase Plasmid (h2) - sc-417828-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β CRISPR Activation Plasmid (h) - sc-417828-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β CRISPR Activation Plasmid (h2) - sc-417828-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β Lentiviral Activation Particles (h) - sc-417828-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β Lentiviral Activation Particles (h2) - sc-417828-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAP LC3β siRNA (h) - sc-43390 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAP LC3β shRNA Plasmid (h) - sc-43390-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAP LC3β shRNA (h) Lentiviral Particles - sc-43390-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LC3B/MAP1LC3B RNAi - H00081631-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU002651 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12978 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12978 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAP1LC3B siRNA (Human) - CRJ3037 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MAP1LC3B (NM_022818.4) - SHH337487 from Creative biogene Category siRNA Species Reactivities Human

Human MAP1LC3B siRNA - orb273538 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MAP1LC3B shRNA Plasmid (Human) - CHJ3037 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MAP1LC3B miRNA 3'UTR clone - MiUTR3H-10707 from Creative biogene Species Reactivities Human

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