DOC2B

Gene Symbol DOC2B
Entrez Gene 8447
Alt Symbol DOC2BL
Species Human
Gene Type protein-coding
Description double C2-like domains, beta
Other Description doc2-beta|double C2-like domain-containing protein beta
Swissprots Q14184
Accessions EAW90677 Q14184 AI478508 BC152720 AAI52721 BC153024 AAI53025 BM713588 D70830 BAA11107 DN831650 XM_011535363 XP_011533665 XR_942188 XR_942189 XR_942190 NM_003585 NP_003576
Function Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level). {ECO:0000269|PubMed:17548353, ECO:0000269|PubMed:8554557}.

DOC2B peptide - ab119812 from Abcam

Category Peptide

Human DOC2B full length protein - ab132855 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab132855 stained with Coomassie Blue.

Recombinant Human DOC2B Protein - H00008447-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

DOC2B - H00008447-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

DOC2B - H00008447-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

DOC2B fusion protein - Ag18584 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

DOC2B fusion protein - ag18684 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human DOC2B, GST-tagged - DOC2B-12115H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Double C2-like domain-containing protein beta(DOC2B) - CSB-YP618877HU CSB-EP618877HU CSB-BP618877HU CSB-MP618877HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DOC2B - TP318949 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
DOC2B

DOC2B Recombinant Protein Antigen - NBP2-13930PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Double C2-like domain-containing protein beta (DOC2B), Recombinant Protein - MBS1365432 from MyBioSource

Category Protein
Prices $1,185.00, $1,185.00, $1,415.00, $1,415.00, $1,890.00, $1,890.00, $2,350.00, $2,350.00, $2,350.00, $3,730.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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