Gene Symbol | DOC2B |
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Entrez Gene | 8447 |
Alt Symbol | DOC2BL |
Species | Human |
Gene Type | protein-coding |
Description | double C2-like domains, beta |
Other Description | doc2-beta|double C2-like domain-containing protein beta |
Swissprots | Q14184 |
Accessions | EAW90677 Q14184 AI478508 BC152720 AAI52721 BC153024 AAI53025 BM713588 D70830 BAA11107 DN831650 XM_011535363 XP_011533665 XR_942188 XR_942189 XR_942190 NM_003585 NP_003576 |
Function | Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}. |
Tissue Specificity | Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level). {ECO:0000269|PubMed:17548353, ECO:0000269|PubMed:8554557}. |
DOC2B peptide - ab119812 from Abcam
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Human DOC2B full length protein - ab132855 from Abcam
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Recombinant Human DOC2B Protein - H00008447-P01 from Novus Biologicals
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DOC2B - H00008447-P01-10 from Acris Antibodies
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DOC2B - H00008447-P01-25 from Acris Antibodies
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DOC2B fusion protein - Ag18584 from Proteintech Group
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DOC2B fusion protein - ag18684 from Proteintech Group
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Recombinant Human DOC2B, GST-tagged - DOC2B-12115H from Creative Biomart
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Recombinant Human Double C2-like domain-containing protein beta(DOC2B) - CSB-YP618877HU CSB-EP618877HU CSB-BP618877HU CSB-MP618877HU from Cusabio
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DOC2B - TP318949 from Acris Antibodies
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DOC2B Recombinant Protein Antigen - NBP2-13930PEP from Novus Biologicals
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Double C2-like domain-containing protein beta (DOC2B), Recombinant Protein - MBS1365432 from MyBioSource
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