Gene Symbol | DOC2B |
---|---|
Entrez Gene | 8447 |
Alt Symbol | DOC2BL |
Species | Human |
Gene Type | protein-coding |
Description | double C2-like domains, beta |
Other Description | doc2-beta|double C2-like domain-containing protein beta |
Swissprots | Q14184 |
Accessions | EAW90677 Q14184 AI478508 BC152720 AAI52721 BC153024 AAI53025 BM713588 D70830 BAA11107 DN831650 XM_011535363 XP_011533665 XR_942188 XR_942189 XR_942190 NM_003585 NP_003576 |
Function | Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Cytoplasmic granule {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}. |
Tissue Specificity | Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level). {ECO:0000269|PubMed:17548353, ECO:0000269|PubMed:8554557}. |
DOC2B CRISPR/Cas9 KO Plasmid (h) - sc-411176 from Santa Cruz Biotechnology
|
||||||||
DOC2B HDR Plasmid (h) - sc-411176-HDR from Santa Cruz Biotechnology
|
||||||||
DOC2B Double Nickase Plasmid (h) - sc-411176-NIC from Santa Cruz Biotechnology
|
||||||||
DOC2B Double Nickase Plasmid (h2) - sc-411176-NIC-2 from Santa Cruz Biotechnology
|
||||||||
DOC2B CRISPR Activation Plasmid (h) - sc-411176-ACT from Santa Cruz Biotechnology
|
||||||||
DOC2B CRISPR Activation Plasmid (h2) - sc-411176-ACT-2 from Santa Cruz Biotechnology
|
||||||||
DOC2B Lentiviral Activation Particles (h) - sc-411176-LAC from Santa Cruz Biotechnology
|
||||||||
DOC2B Lentiviral Activation Particles (h2) - sc-411176-LAC-2 from Santa Cruz Biotechnology
|
||||||||
DOC2BL siRNA (h) - sc-93902 from Santa Cruz Biotechnology
|
||||||||
DOC2BL shRNA Plasmid (h) - sc-93902-SH from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU111321 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN7413 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7413 from Sigma-Aldrich
|
||||||||
DOC2B siRNA (Human) - CRH5535 from Cohesion Biosciences
|
||||||||
DOC2B RNAi - H00008447-R01 from Novus Biologicals
|
||||||||
DOC2B - MBS8237064 from MyBioSource
|
||||||||
Human DOC2B siRNA - orb266037 from Biorbyt
|
||||||||
DOC2B shRNA Plasmid (Human) - CHH5535 from Cohesion Biosciences
|
||||||||