CACNA1D

Gene Symbol CACNA1D
Entrez Gene 776
Alt Symbol CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, PASNA, SANDD
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, L type, alpha 1D subunit
Other Description calcium channel, L type, alpha-1 polypeptide|calcium channel, neuroendocrine/brain-type, alpha 1 subunit|voltage-dependent L-type calcium channel subunit alpha-1D|voltage-gated calcium channel alpha 1 subunit|voltage-gated calcium channel alpha subunit Cav1.3
Swissprots Q71UT1 Q13916 Q9UDC3 Q01668 Q13931 B0FYA3
Accessions AAD08651 BAA07804 EAW65286 EAW65287 EAW65288 EAW65289 EAW65290 EAW65291 EAW65292 EAW65293 EAW65294 EAW65295 Q01668 AB209171 BAD92408 AK294397 BAH11755 AK294585 BAG57776 AW008794 EU363339 ABY66526 M76558 AAA58402 M83566 AAA35629 XM_005265448 XP_005265505 XM_011534094 XP_011532396 XM_011534095 XP_011532397 XM_011534096 XP_011532398 XM_011534097 XP_011532399 XM_011534098 XP_011532400 XM_011534099 XP_011532401 XM_011534100 XP_011532402 NM_000720 NP_000711 NM_001128839 NP_001122311 NM_001128840 NP_001122312
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO:0000269|PubMed:18482979}.
Subcellular Location Membrane {ECO:0000269|PubMed:18482979}; Multi-pass membrane protein {ECO:0000269|PubMed:18482979}.
Tissue Specificity Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle. {ECO:0000269|PubMed:1335101}.
Top Pathways Oxytocin signaling pathway, Calcium signaling pathway, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Circadian entrainment

CaV1.3 peptide - ab196510 from Abcam

Category Peptide

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) - RPF237Hu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Human

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) - RPF237Mu01 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) - RPF237Mu02 from Uscn Life Science Inc.

Category Protein
Source E.coli
Species Mouse

Recombinant Calcium Channel, Voltage Dependent, L-Type, Alpha 1D Subunit (CACNa1D) - RPF237Hu01 from Cloud-clone

Category Protein
Source E.coli
Species Human

Recombinant Human Voltage-dependent L-type calcium channel subunit alpha-1D(CACN - CSB-YP004400HU CSB-EP004400HU CSB-BP004400HU CSB-MP004400HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D), partial, Recombinant Protein - MBS953753 from MyBioSource

Category Protein
Prices $1,375.00, $1,835.00
Sizes 1 mg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast
Species Human

Cav1.3 Recombinant Protein Antigen - NBP1-86684PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 ┬Ál
Source E.coli
Species Human

CACNA1D Peptide, Human - M34GP02255H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
Search more