DAGLA

Gene Symbol DAGLA
Entrez Gene 747
Alt Symbol C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR
Species Human
Gene Type protein-coding
Description diacylglycerol lipase, alpha
Other Description DGL-alpha|neural stem cell-derived dendrite regulator|sn1-specific diacylglycerol lipase alpha
Swissprots Q6WQJ0 Q9Y4D2 A7E233
Accessions EAW73959 EAW73960 EAW73961 EAW73962 Q9Y4D2 AB014559 BAA31634 AI702626 AY275377 AAQ17119 BC150176 AAI50177 BC150195 AAI50196 BC152453 AAI52454 BI963857 XM_005274230 XP_005274287 XM_011545235 XP_011543537 XM_011545236 XP_011543538 NM_006133 NP_006124
Function Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269|PubMed:14610053}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Highly expressed in brain and pancreas. {ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:16051747}.
Top Pathways Retrograde endocannabinoid signaling

DAG Lipase α (D3G8H) Rabbit mAb - 13626 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3G8H
Western blot analysis of extracts from various tissues using DAG Lipase α (D3G8H) Rabbit mAb.

DAGLα (C-14) - sc-133307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DAGLα (C-14): sc-133307. Western blot analysis of DAGLα expression in mouse skeletal muscle tissue extract.

DAGLα (H-156) - sc-292130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DAGLα (N-13) - sc-133308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
DAGLα (N-13): sc-133308. Western blot analysis of DAGLα expression in mouse skeletal muscle tissue extract.

Anti-DAGLA antibody - ab81984 from Abcam

Prices $380.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-DAGLA antibody (ab81984) at 0.3 µg/ml + human liver lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-DAGLA antibody - ab106979 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab106979 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab106979 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-DAGLA antibody - C-terminal - ab192708 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, AP) - LS-C255841 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, APC) - LS-C255842 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, Biotin) - LS-C255844 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, FITC) - LS-C255845 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, Azide-free, HRP) - LS-C255846 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345, PE) - LS-C255847 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa324-354) - LS-C320737 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DAGLA Antibody (aa317-345) - LS-C167264 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DAGLA antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-DAGLA Antibody (aa1031-1042) IHC-plus™ - LS-B3123 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DAGLA antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3123 concentration 5 ug/ml.

DAGLA Antibody - NBP2-31856 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: DAGLA Antibody [NBP2-31856] - Staining of human hippocampus shows moderate nuclear positivity in neuronal cells.

DAGLA Antibody - NBP1-20905 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

DAGLA Polyclonal Antibody - bs-11833R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11833R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11833R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11833R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11833R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, Cy3 Conjugated - bs-11833R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DAGLA Polyclonal Antibody, Cy5 Conjugated - bs-11833R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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