| Gene Symbol | DAGLA |
|---|---|
| Entrez Gene | 747 |
| Alt Symbol | C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR |
| Species | Human |
| Gene Type | protein-coding |
| Description | diacylglycerol lipase, alpha |
| Other Description | DGL-alpha|neural stem cell-derived dendrite regulator|sn1-specific diacylglycerol lipase alpha |
| Swissprots | Q6WQJ0 Q9Y4D2 A7E233 |
| Accessions | EAW73959 EAW73960 EAW73961 EAW73962 Q9Y4D2 AB014559 BAA31634 AI702626 AY275377 AAQ17119 BC150176 AAI50177 BC150195 AAI50196 BC152453 AAI52454 BI963857 XM_005274230 XP_005274287 XM_011545235 XP_011543537 XM_011545236 XP_011543538 NM_006133 NP_006124 |
| Function | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269|PubMed:14610053}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Highly expressed in brain and pancreas. {ECO:0000269|PubMed:14610053, ECO:0000269|PubMed:16051747}. |
| Top Pathways | Retrograde endocannabinoid signaling |