IFIT1

Gene Symbol IFIT1
Entrez Gene 3434
Alt Symbol C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
Species Human
Gene Type protein-coding
Description interferon-induced protein with tetratricopeptide repeats 1
Other Description interferon, alpha-inducible protein (MW 56kD)|interferon-induced 56 kDa protein|interferon-inducible mRNA 561
Swissprots B3KS50 Q96QM5 Q5T7J1 P09914 D3DR31
Accessions CAA29802 EAW50136 EAW50137 EAW50138 P09914 AK092813 BAG52612 AK308688 AK314588 BAG37163 AL548182 AL711085 BC007091 AAH07091 BI670242 BT006667 AAP35313 BU625391 CA306581 CD106320 DA822484 DB003897 DB180094 DB474377 DQ893534 ABM84460 DQ893755 ABM84681 X03557 CAA27244 NM_001270927 NP_001257856 NM_001270928 NP_001257857 NM_001270929 NP_001257858 NM_001270930 NP_001257859 NM_001548 NP_001539
Function Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}.
Top Pathways Hepatitis C, Herpes simplex infection

IFIT1 Antibody - 12082 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated (-) or treated with Human Interferon-α1 (hIFN-α1) #8927 (10 ng/ml, 16 hr; +), using IFIT1 Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

IFIT1 (H-50) - sc-134948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IFIT1 (H-50): sc-134948. Western blot analysis of IFIT1 expression in IFNα treated Daudi (A) and IFNα treated HeLa (B) whole cell lysates.

IFIT1 (N-16) - sc-82946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IFIT1 (N-16): sc-82946. Western blot analysis of IFIT1 expression in non-transfected: sc-117752 (A) and human IFIT1 transfected: sc-171775 (B) 293T whole cell lysates.

Anti-IFIT1 antibody - ab137632 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab137632 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab137632 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-IFIT1 antibody - ab70023 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IFIT1 antibody (ab70023) at 1/500 dilutionLane 1 : IFIT1 transfected 293T lysateLane 2 : Non transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-IFIT1 antibody - ab75340 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IFIT1 antibody - ab75134 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IFIT1 antibody (ab75134) at 1/500 dilutionLane 1 : Extracts from LOVO cellsLane 2 : Extracts from LOVO cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-IFIT1 antibody [3G8] - ab118062 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
All lanes : Anti-IFIT1 antibody [3G8] (ab118062) at 1/500 dilutionLane 1 : HEK293T cell lyaste, transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY IFIT1 cDNA Lysates/proteins at 5 µg per lane.

Anti-IFIT1 antibody - C-terminal - ab135250 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IFIT1 antibody - C-terminal (ab135250) at 1 µg/ml + Human fetal stomach lysate at 10 µg

Anti-IFIT1 / ISG56 Antibody (clone 3G8) - LS-C175767 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
IHC of paraffin-embedded Human liver tissue using anti-IFIT1 mouse monoclonal antibody.

Anti-IFIT1 / ISG56 Antibody - LS-C308387 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IFIT1 / ISG56 Antibody (His63) - LS-C192063 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFIT1 / ISG56 Antibody (C-Terminus) - LS-C144905 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IFIT1 / ISG56 Antibody - LS-C310697 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IFIT1 / ISG56 Antibody - LS-C310699 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFIT1 / ISG56 Antibody (aa270-319) - LS-C151454 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IFIT1 / ISG56 antibody Western Blot of Fetal Stomach.

Anti-IFIT1 / ISG56 Antibody (aa41-90) - LS-C119527 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from LOVO cells, using IFIT1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-IFIT1 / ISG56 Antibody (C-Terminus) - LS-C345670 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of IFIT1 Antibody with human Fetal Kidney lysate.

Anti-IFIT1 / ISG56 Antibody (aa100-148) - LS-C187049 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. IFIT1 antibody dilution 1.0 ug/ml.

Anti-IFIT1 / ISG56 Antibody (C-Terminus) IHC-plus™ - LS-B12059 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

IFIT1 Antibody (3G8) - NBP2-02340 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
Western Blot: IFIT1 Antibody (3G8) [NBP2-02340] Analysis of extracts (35ug) from 9 different cell lines by using anti-IFIT1 monoclonal antibody.

IFIT1 Antibody - NBP2-33751 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: IFIT1 Antibody [NBP2-33751] - Immunofluorescent staining of human cell line HeLa shows localization to cytosol.

IFIT1 Antibody - NBP1-32329 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IFIT1 Antibody [NBP1-32329] - [NBP1-32329- (30 ug of whole cell lysate) A:HeLa S3 7.5% SDS PAGE diluted at 1:500

IFIT1 Antibody - NBP1-18710 from Novus Biologicals

Prices $329.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

IFIT1 Antibody - 43780002 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: IFIT1 Antibody [43780002]
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