IFIT1

Gene Symbol	IFIT1
Entrez Gene	3434
Alt Symbol	C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561
Species	Human
Gene Type	protein-coding
Description	interferon-induced protein with tetratricopeptide repeats 1
Other Description	interferon, alpha-inducible protein (MW 56kD)|interferon-induced 56 kDa protein|interferon-inducible mRNA 561
Swissprots	B3KS50 Q96QM5 Q5T7J1 P09914 D3DR31
Accessions	CAA29802 EAW50136 EAW50137 EAW50138 P09914 AK092813 BAG52612 AK308688 AK314588 BAG37163 AL548182 AL711085 BC007091 AAH07091 BI670242 BT006667 AAP35313 BU625391 CA306581 CD106320 DA822484 DB003897 DB180094 DB474377 DQ893534 ABM84460 DQ893755 ABM84681 X03557 CAA27244 NM_001270927 NP_001257856 NM_001270928 NP_001257857 NM_001270929 NP_001257858 NM_001270930 NP_001257859 NM_001548 NP_001539
Function	Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}.
Top Pathways	Hepatitis C, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), Human, ELISA Kit - CSB-EL011018HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Interferon-induced protein with tetratricopeptide repeats 1, IFIT1, Human, ELISA Kit - E14985h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1), Human, CLIA Kit - SCL609Hu from ARP American Research Products Category CLIA Kit Prices $783.00 Sizes 96 t Sensitivity 0.054ng/mL Range 0.156-10ng/mL

IFIT1 (Human) IP-WB Antibody Pair - H00003434-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human Interferon-induced protein with tetratricopeptide repeats 1(IFIT1) ELISA k - CSB-EL011018HU from Cusabio Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

interferon-induced protein with tetratricopeptide repeats 1, ELISA Kit - MBS925861 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human IFIT1 is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 15.6 pg/ml -1000 pg/ml.

Human IFIT1 / ISG56 ELISA Kit (Sandwich ELISA) - LS-F13244 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

IFIT1 - EKH3394 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

IFIT1 ELISA Kit (Human) : 96 Wells (OKEH02414) - OKEH02414 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.078 ng/mL Range 0.156 - 10 ng/mL

Human IFIT1 ELISA Kit - E020383 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human IFIT1 is typically less than 3.9 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

Human Interferon-induced protein with tetratricopeptide repeats 1 ELISA Kit - EK3540 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.078ng/ml Range 0.156-10 ng/mL

Interferon-induced protein with tetratricopeptide repeats 1, ELISA Kit - MBS2883676 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Interferon-induced protein with tetratricopeptide repeats 1, ELISA Kit - MBS9427374 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.078ng/mL Range 0.156-10 ng/mL

Interferon-induced protein with tetratricopeptide repeats 1, ELISA Kit - MBS764150 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human IFIT1 / ISG56 ELISA Kit (Sandwich ELISA) - LS-F34744 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

Human IFIT1 ELISA Kit - orb404645 from Biorbyt Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

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