| Gene Symbol | IFIT1 |
|---|---|
| Entrez Gene | 3434 |
| Alt Symbol | C56, G10P1, IFI-56, IFI-56K, IFI56, IFIT-1, IFNAI1, ISG56, P56, RNM561 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon-induced protein with tetratricopeptide repeats 1 |
| Other Description | interferon, alpha-inducible protein (MW 56kD)|interferon-induced 56 kDa protein|interferon-inducible mRNA 561 |
| Swissprots | B3KS50 Q96QM5 Q5T7J1 P09914 D3DR31 |
| Accessions | CAA29802 EAW50136 EAW50137 EAW50138 P09914 AK092813 BAG52612 AK308688 AK314588 BAG37163 AL548182 AL711085 BC007091 AAH07091 BI670242 BT006667 AAP35313 BU625391 CA306581 CD106320 DA822484 DB003897 DB180094 DB474377 DQ893534 ABM84460 DQ893755 ABM84681 X03557 CAA27244 NM_001270927 NP_001257856 NM_001270928 NP_001257857 NM_001270929 NP_001257858 NM_001270930 NP_001257859 NM_001548 NP_001539 |
| Function | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses. {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:19416887, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:23334420}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19008854, ECO:0000269|PubMed:21642987}. |
| Top Pathways | Hepatitis C, Herpes simplex infection |