| Gene Symbol |
A2ML1
|
| Entrez Gene |
144568
|
| Alt Symbol |
CPAMD9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
alpha-2-macroglobulin-like 1
|
| Other Description |
C3 and PZP-like, alpha-2-macroglobulin domain containing 9|alpha-2-macroglobulin-like protein 1
|
| Swissprots |
B7Z7V4 Q96LQ8 Q6ZW52 F5H2Z2 Q8N1M4 A8K2U0 Q2M224 Q6ZW53 D3DUV3 B5MDD1
|
| Accessions |
A8K2U0 EAW88602 EAW88603 EAW88604 EAW88605 EAW88606 EAW88607 AK057908 BAB71612 AK096448 BAC04793 AK122624 BAC85494 AK123591 BAC85653 AK123592 BAC85654 AK123601 BAG53918 AK290355 BAF83044 AK302555 BAH13740 AL832139 AL832750 AL833479 BC093840 AAH93840 BC112131 AAI12132 BC172370 AAI72370 BF330285 BF354222 BX647674 BX648231 DA436610 DA456454 DA461408 EL594621 XM_011520566 XP_011518868 XM_011520567 XP_011518869 XR_931275 NM_001282424 NP_001269353 NM_144670 NP_653271
|
| Function |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:16298998}.
|
| Tissue Specificity |
In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon. {ECO:0000269|PubMed:16298998}.
|
![Western Blot: A2ML1 Overexpression Lysate [H00144568-T01] - Lane 1: A2ML1 transfected lysate (17.49 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/4745_A2ML1%2520Overexpression%2520Lysate-Western%2520Blot-H00144568-T01-img0001.jpg)