A2ML1

Gene Symbol A2ML1
Entrez Gene 144568
Alt Symbol CPAMD9
Species Human
Gene Type protein-coding
Description alpha-2-macroglobulin-like 1
Other Description C3 and PZP-like, alpha-2-macroglobulin domain containing 9|alpha-2-macroglobulin-like protein 1
Swissprots B7Z7V4 Q96LQ8 Q6ZW52 F5H2Z2 Q8N1M4 A8K2U0 Q2M224 Q6ZW53 D3DUV3 B5MDD1
Accessions A8K2U0 EAW88602 EAW88603 EAW88604 EAW88605 EAW88606 EAW88607 AK057908 BAB71612 AK096448 BAC04793 AK122624 BAC85494 AK123591 BAC85653 AK123592 BAC85654 AK123601 BAG53918 AK290355 BAF83044 AK302555 BAH13740 AL832139 AL832750 AL833479 BC093840 AAH93840 BC112131 AAI12132 BC172370 AAI72370 BF330285 BF354222 BX647674 BX648231 DA436610 DA456454 DA461408 EL594621 XM_011520566 XP_011518868 XM_011520567 XP_011518869 XR_931275 NM_001282424 NP_001269353 NM_144670 NP_653271
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.
Subcellular Location Secreted {ECO:0000269|PubMed:16298998}.
Tissue Specificity In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon. {ECO:0000269|PubMed:16298998}.

α2ML1 CRISPR/Cas9 KO Plasmid (h) - sc-414544 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 HDR Plasmid (h) - sc-414544-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 Double Nickase Plasmid (h) - sc-414544-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 Double Nickase Plasmid (h2) - sc-414544-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 CRISPR Activation Plasmid (h) - sc-414544-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 CRISPR Activation Plasmid (h2) - sc-414544-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 Lentiviral Activation Particles (h) - sc-414544-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 Lentiviral Activation Particles (h2) - sc-414544-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α2ML1 siRNA (h) - sc-95683 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α2ML1 shRNA Plasmid (h) - sc-95683-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α2ML1 shRNA (h) Lentiviral Particles - sc-95683-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU078161 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2595 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2595 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06011 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06011

shRNA set against Human A2ML1 (NM_144670.4) - SHH228282 from Creative biogene

Category siRNA
Species Reactivities Human

A2ML1 miRNA 3'UTR clone - MiUTR4H-TG00003 from Creative biogene

Species Reactivities Human
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