CSF1R

Gene Symbol	CSF1R
Entrez Gene	1436
Alt Symbol	C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species	Human
Gene Type	protein-coding
Description	colony stimulating factor 1 receptor
Other Description	CD115 antigen|CSF-1 receptor|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|macrophage colony-stimulating factor 1 receptor|proto-oncogene c-Fms
Swissprots	D3DQG2 P07333 Q6LDY4 B5A955 Q86VW7 Q6LDW5
Accessions	AAA35848 AAA35849 AAA88039 AAB51235 AAB51696 CAJ32237 CAV32774 CBX55881 CCA65436 EAW61749 EAW61750 P07333 AB208819 BAD92056 AI863331 AK294467 BAG57697 AK304491 BAG65300 BC047521 AAH47521 BC129939 AAI29940 BM562096 BM825705 BQ028933 BX648599 CD620053 DA219251 DR001419 EU826593 ACF47629 M14193 AAA35834 M25786 AAA58421 X03663 CAA27300 NM_001288705 NP_001275634 NM_005211 NP_005202 NR_109969
Function	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in bone marrow and in differentiated blood mononuclear cells.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Endocytosis, Osteoclast differentiation, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MCSF Receptor protein fragment - ab155619 from Abcam Category Protein Prices $302.00 Sizes 200 µg Source HEK 293 cells Species Human

Human M-CSF Receptor - Fc Chimera - ab83682 from Abcam Prices $315.00 Sizes 25 µg Source HEK 293 cells Species Human

Active human MCSF Receptor protein fragment - ab56259 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Insect cells Species Human

Human MCSF Receptor protein fragment - ab158211 from Abcam Category Protein Source Wheat germ Species Human

CSF1R / CD115 / FMS Antibody Blocking Peptide - LS-E2805 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSF1R / CD115 / FMS Antibody Blocking Peptide - LS-E27447 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSF1R / CD115 / FMS Antibody Blocking Peptide - LS-E27448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CSF1R / CD115 / FMS Antibody Blocking Peptide - LS-E9093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

M-CSF R/CD115 Partial Recombinant Protein - H00001436-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

M-CSF R/CD115 Recombinant Protein - P4534 from Novus Biologicals Category Protein Prices $429.00 Sizes 10 µg Species Human

Recombinant Human M-CSF R/CD115 Protein - P4672 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

M-CSF R Peptide - P2614 from Novus Biologicals Category Peptide Species Human

MCSF-Receptor-CSF1R-Antibody-C-term-Blocking-peptide - BP7604b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MCSF-Receptor-CSF1R-Antibody-N-term-Blocking-peptide - BP7604a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human M-CSF R Fc Chimera - 329-MR-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Human M-CSF R Fc Chimera, CF - 329-MR-100/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

E.coli fim2 protein - orb244728 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

Human MCFSR Protein - abx066040 from Abbexa Category Protein Source E.coli Species Human

MCSF Receptor Peptide - AC21-2271-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MCSF Receptor Peptide - AC21-2272-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD115 - H00001436-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD115 - H00001436-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD115 - P4672 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

CD115 - P5715 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Colony Stimulating Factor ReceptorMacrophage Human - 20-7765 from ARP American Research Products Category Protein Prices $495.00 Sizes 50 µg Source E.coli Species Human

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