CSF1R

Gene Symbol	CSF1R
Entrez Gene	1436
Alt Symbol	C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species	Human
Gene Type	protein-coding
Description	colony stimulating factor 1 receptor
Other Description	CD115 antigen|CSF-1 receptor|FMS proto-oncogene|McDonough feline sarcoma viral (v-fms) oncogene homolog|macrophage colony stimulating factor I receptor|macrophage colony-stimulating factor 1 receptor|proto-oncogene c-Fms
Swissprots	D3DQG2 P07333 Q6LDY4 B5A955 Q86VW7 Q6LDW5
Accessions	AAA35848 AAA35849 AAA88039 AAB51235 AAB51696 CAJ32237 CAV32774 CBX55881 CCA65436 EAW61749 EAW61750 P07333 AB208819 BAD92056 AI863331 AK294467 BAG57697 AK304491 BAG65300 BC047521 AAH47521 BC129939 AAI29940 BM562096 BM825705 BQ028933 BX648599 CD620053 DA219251 DR001419 EU826593 ACF47629 M14193 AAA35834 M25786 AAA58421 X03663 CAA27300 NM_001288705 NP_001275634 NM_005211 NP_005202 NR_109969
Function	Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in bone marrow and in differentiated blood mononuclear cells.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Endocytosis, Osteoclast differentiation, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Fms/CSF-1R CRISPR/Cas9 KO Plasmid (h) - sc-400416 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R HDR Plasmid (h) - sc-400416-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R Double Nickase Plasmid (h) - sc-400416-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R Double Nickase Plasmid (h2) - sc-400416-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R CRISPR Activation Plasmid (h) - sc-400416-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R CRISPR Activation Plasmid (h2) - sc-400416-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R Lentiviral Activation Particles (h) - sc-400416-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R Lentiviral Activation Particles (h2) - sc-400416-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Fms/CSF-1R siRNA (h) - sc-29220 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Fms/CSF-1R shRNA Plasmid (h) - sc-29220-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Fms/CSF-1R shRNA (h) Lentiviral Particles - sc-29220-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

M-CSF R/CD115 RNAi - H00001436-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU052661 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0496 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0497 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0498 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1014 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1014 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CSF1R siRNA (Human) - CRH1010 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CSF1R - MBS8218688 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CSF1R (NM_005211.3) - SHH270229 from Creative biogene Category siRNA Species Reactivities Human

Human CSF1R siRNA - orb261512 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CSF1R shRNA Plasmid (Human) - CHH1010 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CSF1R miRNA 3'UTR clone - MiUTR3H-01600 from Creative biogene Species Reactivities Human

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