| Gene Symbol |
PPARG
|
| Entrez Gene |
5468
|
| Alt Symbol |
CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peroxisome proliferator-activated receptor gamma
|
| Other Description |
PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1
|
| Swissprots |
Q15180 B5BUA1 O14515 O00684 Q15179 O00710 Q96J12 Q86U60 P37231 A8K3G6 Q15832 Q0QJH8 Q15178
|
| Accessions |
AAK17925 AAN38992 BAA23353 BAA23354 CBX54350 EAW64123 EAW64124 EAW64125 P37231 AB097931 BAD20647 AB107271 BAD34540 AB307692 BAH02283 AB451337 BAG70151 AB451486 BAG70300 AB472042 BAI63629 AB565476 BAM71699 AJ563369 CAD91388 AJ563370 CAD91389 AJ698135 CAG29019 AK223528 BAD97248 AK290581 BAF83270 AL523434 BC006811 AAH06811 BG323933 BI820841 BM923992 BQ925271 BT007281 AAP35945 D83233 BAA18949 DQ356894 ABC97372 DQ891108 ABM82034 DQ894289 ABM85215 HQ692866 ADZ17377 U63415 AAB04028 U79012 AAC51248 X90563 CAA62152 XM_011533840 XP_011532142 XM_011533841 XP_011532143 XM_011533842 XP_011532144 XM_011533843 XP_011532145 XM_011533844 XP_011532146 NM_005037 NP_005028 NM_015869 NP_056953 NM_138711 NP_619725 NM_138712 NP_619726
|
| Function |
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.
|
| Tissue Specificity |
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269|PubMed:9065481}.
|
| Top Pathways |
Huntington's disease, PPAR signaling pathway, Thyroid cancer, Osteoclast differentiation, AMPK signaling pathway
|
![Western Blot: PPAR gamma Overexpression Lysate (Adult Normal) [NBL1-14633] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPAR gamma.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2933_PPAR%2520gamma%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14633-img0002.jpg)
![Western Blot: PPAR gamma Overexpression Lysate (Adult Normal) [NBL1-14635] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPAR gamma.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7626_PPAR%2520gamma%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14635-img0002.jpg)
![Western Blot: PPAR gamma Overexpression Lysate (Adult Normal) [NBL1-14634] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PPAR gamma.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9228_PPAR%2520gamma%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14634-img0002.jpg)