PPARG

Gene Symbol	PPARG
Entrez Gene	5468
Alt Symbol	CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Species	Human
Gene Type	protein-coding
Description	peroxisome proliferator-activated receptor gamma
Other Description	PPAR-gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferator-activated nuclear receptor gamma variant 1
Swissprots	Q15180 B5BUA1 O14515 O00684 Q15179 O00710 Q96J12 Q86U60 P37231 A8K3G6 Q15832 Q0QJH8 Q15178
Accessions	AAK17925 AAN38992 BAA23353 BAA23354 CBX54350 EAW64123 EAW64124 EAW64125 P37231 AB097931 BAD20647 AB107271 BAD34540 AB307692 BAH02283 AB451337 BAG70151 AB451486 BAG70300 AB472042 BAI63629 AB565476 BAM71699 AJ563369 CAD91388 AJ563370 CAD91389 AJ698135 CAG29019 AK223528 BAD97248 AK290581 BAF83270 AL523434 BC006811 AAH06811 BG323933 BI820841 BM923992 BQ925271 BT007281 AAP35945 D83233 BAA18949 DQ356894 ABC97372 DQ891108 ABM82034 DQ894289 ABM85215 HQ692866 ADZ17377 U63415 AAB04028 U79012 AAC51248 X90563 CAA62152 XM_011533840 XP_011532142 XM_011533841 XP_011532143 XM_011533842 XP_011532144 XM_011533843 XP_011532145 XM_011533844 XP_011532146 NM_005037 NP_005028 NM_015869 NP_056953 NM_138711 NP_619725 NM_138712 NP_619726
Function	Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.
Subcellular Location	Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. CCRN4L/NOC enhances its nuclear translocation.
Tissue Specificity	Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269|PubMed:9065481}.
Top Pathways	Huntington's disease, PPAR signaling pathway, Thyroid cancer, Osteoclast differentiation, AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPAR gamma full length protein - ab53382 from Abcam Category Protein Source E. coli Species Human

Human PPAR gamma full length protein - ab81807 from Abcam Category Protein Source E. coli Species Human

Human PPAR gamma peptide - ab32241 from Abcam Category Peptide

Human PPAR gamma protein fragment - ab83647 from Abcam Category Protein Source E. coli Species Human

Human PPAR gamma protein fragment - ab159162 from Abcam Category Protein Source Wheat germ Species Human

Human PPAR gamma protein fragment - ab81850 from Abcam Category Protein Source E. coli Species Human

Human PPAR gamma protein fragment - ab82032 from Abcam Category Protein Source E. coli Species Human

Human PPAR gamma 2 peptide - ab41762 from Abcam Category Peptide Species Human

Mouse PPAR gamma 1+2 peptide - ab45277 from Abcam Category Peptide

PPARG / PPAR Gamma Antibody Blocking Peptide - LS-E8015 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARG / PPAR Gamma Antibody Blocking Peptide - LS-E14142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARG / PPAR Gamma Antibody Blocking Peptide - LS-E14141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPARG / PPAR Gamma Antibody Blocking Peptide - LS-E11577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPAR gamma/NR1C3 Recombinant Protein - H00005468-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PPAR gamma/NR1C3 Partial Recombinant Protein - H00005468-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PPAR gamma/NR1C3 Protein - NBP1-45290 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

PPAR gamma/NR1C3 Protein - NBP1-99904 from Novus Biologicals Category Protein Prices $349.00 Sizes 10 µg Species Human

PPARG-Antibody-N-term-Blocking-Peptide - BP19438a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPARG-Antibody-N-term-Blocking-peptide - BP5863a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPARG Protein (OPPA01141) - OPPA01141 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

PPARG Protein (OPPA01190) - OPPA01190 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human Peroxisome Proliferator Activated Receptor Gamma protein - orb80860 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E.coli Species Human

Human PPARG protein - orb244455 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PPARG protein (GST Tag) - orb139505 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

PPARG peptide - orb217779 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

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