| Gene Symbol |
UBE2A
|
| Entrez Gene |
7319
|
| Alt Symbol |
HHR6A, MRXS30, MRXSN, RAD6A, UBC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2A
|
| Other Description |
RAD6 homolog A|ubiquitin carrier protein A|ubiquitin-conjugating enzyme E2 A|ubiquitin-protein ligase A
|
| Swissprots |
Q96FX4 A6NMF5 P49459 B2R7R9 D3DWI1 A6NGR2 Q4TTG1 A6NFE9
|
| Accessions |
AAL58874 AAY46159 CBX53867 CBX53868 CBX53869 EAW89861 EAW89862 EAW89863 P49459 AI784380 AK223045 BAD96765 AK223064 BAD96784 AK297696 BAG60054 AK301675 BAG63148 AK313092 BAG35916 AL701289 BC010175 AAH10175 BC042021 BI093289 D28459 BAA05825 DA068506 DA599154 DQ893386 ABM84312 DQ896706 ABM87705 M74524 AAA35981 NM_001282161 NP_001269090 NM_003336 NP_003327 NM_181762 NP_861427 NM_181777
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:20061386}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: UBE2A Overexpression Lysate (Adult Normal) [NBL1-17512] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UBE2A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5174_UBE2A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17512-img0002.jpg)