JAK3

Gene Symbol JAK3
Entrez Gene 3718
Alt Symbol JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Species Human
Gene Type protein-coding
Description Janus kinase 3
Other Description Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase|tyrosine-protein kinase JAK3
Swissprots Q9Y6S2 Q99699 Q8N1E8 Q13259 Q13260 P52333 Q13611
Accessions AAC50950 AAD22741 AAM44860 EAW84637 EAW84638 EAW84639 EAW84640 P52333 AK296383 BAG59055 AK304392 BAG65227 BC028068 AAH28068 BF512748 BM561964 DA405504 U08340 AAA17743 U09607 AAA19626 U31317 AAC50225 U31601 AAC50226 U57096 AAC50542 XM_005259896 XP_005259953 XM_006722745 XP_006722808 XM_011527990 XP_011526292 XM_011527991 XP_011526293 XR_430137 NM_000215 NP_000206
Function Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both
Subcellular Location Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}.
Top Pathways HTLV-I infection, Chemokine signaling pathway, Measles, Jak-STAT signaling pathway, Viral carcinogenesis

Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb - 5031 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D44E3
Western blot analysis of extracts from NK-92 cells, untreated or treated with Human Interleukin-2 (hIL-2) #8907 (10 ng/ml, 15 minutes), using Phospho-Jak3 (Tyr980/981) (D44E3) Rabbit mAb (upper) or Jak3 Antibody #3775 (lower).

Jak3 (D1H3) Rabbit mAb - 8827 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1H3
Western blot analysis of extracts from various cell lines using Jak3 (D1H3) Rabbit mAb.

Jak3 (D7B12) Rabbit mAb - 8863 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7B12
Western blot analysis of extracts from various cell lines using Jak3 (D7B12) Rabbit mAb.

Jak3 Antibody - 3775 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, using Jak3 Antibody.

Jak3 (5H2) Mouse mAb - 5481 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 5H2
Western blot analysis of extracts from various cell lines using Jak3 (5H2) Mouse mAb.

JAK3 (B-12) - sc-6932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
JAK3 (B-12): sc-6932. Western blot analysis of human recombinant JAK3 (A) and HeLa whole cell lysate (B).

JAK3 (A1-14-16) - sc-56921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

JAK3 (C-21) - sc-513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
JAK3 (C-21): sc-513. Western blot analysis of JAK3 expression in HuT 78 (A) and MOLT-4 (B) whole cell lysates.

JAK3 (C-14) - sc-34481 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JAK3 (C-14): sc-34481. Western blot analysis of JAK3 expression in MOLT-4 whole cell lysate.

JAK3 (H-20) - sc-1080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

JAK3 (N-15) - sc-1078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
JAK3 (N-15): sc-1078. Western blot analysis of JAK3 expression in HuT 78 whole cell lysate.

JAK3 (N-19) - sc-34482 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

JAK3 (SPM189) - sc-56419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

JAK3 (3F228) - sc-71461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-JAK3 (Tyr 980) - sc-16567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-JAK3 (Tyr 980)-R: sc-16567-R. Western blot analysis of JAK3 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) Hep G2 whole cell lysates.

Anti-JAK3 (phospho Y785) antibody - ab61102 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61102, at a 1/50 dilution, staining human JAK3 (phospho Y785) in brain, using Immunohistochemistry, Formalin/PFA fixed Paraffin embedded tissue, minus immunising peptide (left image) and plus immunising peptide (right image).

Anti-JAK3 antibody - ab203611 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin embedded mouse lung tissue labeling Jak3 with ab203611 at 1/200 dilution. DAB staining.

Anti-JAK3 antibody - ab125296 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-JAK3 antibody (ab125296) at 1 µg/ml (Milk blocking - 1%) + TF-1 (Human erythroleukaemic cell line) Whole Cell Lysate at 25 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-JAK3 antibody - ab61198 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61198 at 1/50 dilution staining JAK3 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence (left) or presence (right) of the immunising peptide.

Anti-JAK3 antibody - ab78116 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-JAK3 antibody (ab78116) at 1/500 dilution + HeLa cell lysateSecondarydonkey anti-rabbit HRP conjugated IgG at 1/1000 dilution

Anti-JAK3 antibody [5H2] - ab91206 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5H2
Anti-JAK3 antibody [5H2] (ab91206) at 1/500 dilution + Jurkat cell lysate

Anti-JAK3 antibody [EP909Y] - ab45141 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP909Y
Anti-JAK3 antibody [EP909Y] (ab45141) at 1/2000 dilution + TF-1 cell lysate

Anti-JAK3 antibody [EPR908(2)] - ab92595 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR908(2)
All lanes : Anti-JAK3 antibody [EPR908(2)] (ab92595) at 1/1000 dilutionLane 1 : IM-9 cell lysateLane 2 : TF-1 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-JAK3 antibody [MM0784-36P7] - ab201664 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0784-36P7

Anti-JAK3 antibody - N-terminal - ab172870 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-JAK3 antibody - N-terminal (ab172870) at 1/100 dilution + Mouse stomach tissue lysate at 35 µg
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