JAK3

Gene Symbol	JAK3
Entrez Gene	3718
Alt Symbol	JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Species	Human
Gene Type	protein-coding
Description	Janus kinase 3
Other Description	Janus kinase 3 (a protein tyrosine kinase, leukocyte)|leukocyte Janus kinase|tyrosine-protein kinase JAK3
Swissprots	Q9Y6S2 Q99699 Q8N1E8 Q13259 Q13260 P52333 Q13611
Accessions	AAC50950 AAD22741 AAM44860 EAW84637 EAW84638 EAW84639 EAW84640 P52333 AK296383 BAG59055 AK304392 BAG65227 BC028068 AAH28068 BF512748 BM561964 DA405504 U08340 AAA17743 U09607 AAA19626 U31317 AAC50225 U31601 AAC50226 U57096 AAC50542 XM_005259896 XP_005259953 XM_006722745 XP_006722808 XM_011527990 XP_011526292 XM_011527991 XP_011526293 XR_430137 NM_000215 NP_000206
Function	Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both
Subcellular Location	Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue Specificity	In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. {ECO:0000269|PubMed:7535338}.
Top Pathways	HTLV-I infection, Chemokine signaling pathway, Measles, Jak-STAT signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JAK3 CRISPR/Cas9 KO Plasmid (h) - sc-400835 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 HDR Plasmid (h) - sc-400835-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 Double Nickase Plasmid (h) - sc-400835-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 Double Nickase Plasmid (h2) - sc-400835-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 CRISPR Activation Plasmid (h) - sc-400835-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 CRISPR Activation Plasmid (h2) - sc-400835-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 Lentiviral Activation Particles (h) - sc-400835-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 Lentiviral Activation Particles (h2) - sc-400835-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 siRNA (h) - sc-29379 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK3 shRNA Plasmid (h) - sc-29379-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

JAK3 shRNA (h) Lentiviral Particles - sc-29379-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Jak3 RNAi - H00003718-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU135461 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® esiRNA - EHU097101 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1010 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1009 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1011 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN10855 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10855 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05311 from Sigma-Aldrich Category miRNA

JAK3 siRNA (Human) - CRH2504 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

JAK3, siRNA - MBS8222922 from MyBioSource Category siRNA Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human JAK3 (NM_000215.3) - SHH321935 from Creative biogene Category siRNA Species Reactivities Human

JAK3 CRISPR/Cas9 KO Plasmid (h2) - sc-400835-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

JAK3 HDR Plasmid (h2) - sc-400835-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

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