GCGR

Gene Symbol GCGR
Entrez Gene 2642
Alt Symbol GGR, GL-R
Species Human
Gene Type protein-coding
Description glucagon receptor
Other Description -
Swissprots Q2M3M5 P47871
Accessions AAA35897 CAB52383 EAW89684 P47871 AK307234 AK314247 BC104854 AAI04855 BC112041 AAI12042 BJ997148 DA639395 L20316 AAA53628 U03469 AAC52063 XM_006722277 XP_006722340 XM_011523539 XP_011521841 XM_011523540 XP_011521842 NM_000160 NP_000151
Function G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding.
Top Pathways Glucagon signaling pathway, Neuroactive ligand-receptor interaction

GLP-1 (5B10) - sc-57510 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Glucagon Receptor (N-12) - sc-34640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Glucagon Receptor (P-15) - sc-34641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Glucagon Receptor (P-15): sc-34641. Western blot analysis of Glucagon Receptor expression in mouse adrenal gland tissue extract.

Glucagon Receptor (I-16) - sc-34638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Glucagon Receptor (I-16): sc-34638. Western blot analysis of Glucagon Receptor expression in COLO 205 (A), Hep G2 (B) and NIH/3T3 (C) whole cell lysates.

Glucagon Receptor (H-57) - sc-66912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Glucagon Receptor (H-57): sc-66912. Western blot analysis of Glucagon Receptor expression in Caki-1 whole cell lysate.

Anti-Glucagon Receptor antibody - ab75240 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glucagon Receptor antibody (ab75240) at 1/500 dilutionLane 1 : extracts from COLO205 cellsLane 2 : extracts from COLO205 cells with immunizing peptide at 5 µgLysates/proteins at 15 µg per lane.

Anti-Glucagon Receptor antibody - ab109279 from Abcam

Prices $376.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glucagon Receptor antibody (ab109279) at 1/250 dilution (Milk Blocking - 3%)Lane 1 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 3 : SW480 (Human colon adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Glucagon Receptor antibody - C-terminal - ab150581 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labelling Glucagon Receptor with ab150581 at 6 µg/ml.

Anti-Glucagon Receptor antibody - N-terminal - ab137649 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Glucagon Receptor antibody - N-terminal (ab137649) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-GCGR / Glucagon Receptor Antibody (aa441-452) - LS-C61746 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, AP) - LS-C214642 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, APC) - LS-C214643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, Biotin) - LS-C214644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, Azide-free, HRP) - LS-C214646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, FITC) - LS-C214645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody - LS-C294205 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus, PE) - LS-C214647 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (FITC) - LS-C301375 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (Biotin) - LS-C305830 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus) - LS-C321580 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCGR / Glucagon Receptor Antibody (Extracellular Domain) IHC-plus™ - LS-A837 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-GCGR / Glucagon Receptor Antibody (Lys136) - LS-C177156 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Glucagon Receptor (K136) pAb in extracts from PC12 cells.

Anti-GCGR / Glucagon Receptor Antibody (N-Terminus) IHC-plus™ - LS-A4258 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Glucagon Receptor antibody LS-A4258 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GCGR / Glucagon Receptor Antibody (C-Terminus) IHC-plus™ - LS-A4263 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Glucagon Receptor antibody LS-A4263 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GCGR / Glucagon Receptor Antibody (N-Terminus) IHC-plus™ - LS-A4256 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Glucagon Receptor antibody LS-A4256 IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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