GCGR

Gene Symbol GCGR
Entrez Gene 2642
Alt Symbol GGR, GL-R
Species Human
Gene Type protein-coding
Description glucagon receptor
Other Description -
Swissprots Q2M3M5 P47871
Accessions AAA35897 CAB52383 EAW89684 P47871 AK307234 AK314247 BC104854 AAI04855 BC112041 AAI12042 BJ997148 DA639395 L20316 AAA53628 U03469 AAC52063 XM_006722277 XP_006722340 XM_011523539 XP_011521841 XM_011523540 XP_011521842 NM_000160 NP_000151
Function G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:22908259, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}; Multi-pass membrane protein {ECO:0000269|PubMed:19657311, ECO:0000269|PubMed:23863937, ECO:0000269|PubMed:7507321, ECO:0000269|PubMed:9287038}. Note=Is rapidly internalized after ligand-binding.
Top Pathways Glucagon signaling pathway, Neuroactive ligand-receptor interaction

Glucagon Receptor CRISPR/Cas9 KO Plasmid (h) - sc-402018 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor HDR Plasmid (h) - sc-402018-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor Double Nickase Plasmid (h) - sc-402018-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor Double Nickase Plasmid (h2) - sc-402018-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor CRISPR Activation Plasmid (h) - sc-402018-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor CRISPR Activation Plasmid (h2) - sc-402018-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor Lentiviral Activation Particles (h) - sc-402018-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor Lentiviral Activation Particles (h2) - sc-402018-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Glucagon Receptor siRNA (h) - sc-45765 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Glucagon Receptor shRNA Plasmid (h) - sc-45765-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Glucagon Receptor shRNA (h) Lentiviral Particles - sc-45765-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Glucagon R/GCGR RNAi - H00002642-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU217681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9186 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9186 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GCGR siRNA (Human) - CRH1756 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GCGR - MBS8209455 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GCGR (NM_000160.3) - SHH299986 from Creative biogene

Category siRNA
Species Reactivities Human

Human GCGR siRNA - orb262258 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GCGR shRNA Plasmid (Human) - CHH1756 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GCGR miRNA 3'UTR clone - MiUTR3H-00869 from Creative biogene

Species Reactivities Human
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