| Gene Symbol |
CERS1
|
| Entrez Gene |
10715
|
| Alt Symbol |
EPM8, LAG1, LASS1, UOG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ceramide synthase 1
|
| Other Description |
longevity assurance (LAG1, S. cerevisiae) homolog 1|longevity assurance gene 1 protein homolog 1|protein UOG-1|upstream of GDF1
|
| Swissprots |
P27544
|
| Accessions |
AAD16892 EAW84745 EAW84746 P27544 AI671814 AK293463 BAG56958 AL120193 BC032615 BC084582 AAH84582 BF343384 BM925585 BX453803 NM_001290265 NP_001277194 NM_021267 NP_067090 NM_198207 NP_937850
|
| Function |
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Sphingolipid signaling pathway, Sphingolipid metabolism
|
![Western Blot: LASS1 Overexpression Lysate (Adult Normal) [NBP2-04711] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LASS1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3100_LASS1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04711-img0001.jpg)