ADA

Gene Symbol	ADA
Entrez Gene	100
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	adenosine deaminase
Other Description	adenosine aminohydrolase
Swissprots	Q6LA59 P00813 Q53F92
Accessions	AAA78791 CAA26130 CBX85542 CBX85614 EAW75904 EAW75905 EAW75906 EAW75907 P00813 AK123988 AK223397 BAD97117 AL832305 BC007678 AAH07678 BC040226 AAH40226 BI601734 DQ892681 ABM83607 DQ895924 ABM86850 KJ534760 AHW56400 S66773 AAB28742 X02994 CAA26734 XM_005260236 XP_005260293 XM_011528478 XP_011526780 XM_011528479 XP_011526781 XR_244129 NM_000022 NP_000013
Function	Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. {ECO:0000269|PubMed:11772392}.
Subcellular Location	Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
Tissue Specificity	Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.
Top Pathways	Primary immunodeficiency, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ADA full length protein - ab109839 from Abcam Category Protein Prices $410.00, $1,234.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Active human ADA full length protein - ab168085 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source E. coli Species Human

ADA full length protein - ab135018 from Abcam Category Protein Prices $518.00 Sizes 100 µg Source E. coli

Human ADA full length protein - ab112245 from Abcam Category Protein Source Wheat germ Species Human

ADA / Adenosine Deaminase Antibody Blocking Peptide - LS-E1127 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ADA / Adenosine Deaminase Antibody Blocking Peptide - LS-E18554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Adenosine Deaminase/ADA Protein - H00000100-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Adenosine Deaminase/ADA Protein - NBP1-72362 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

ADA-Antibody-C-term-Blocking-peptide - BP11650b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Adenosine Deaminase/ADA, CF - 7048-AD-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met1-Leu363, with a C-terminal 6-His tag

Human ADA protein - orb167853 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E. coli Species Human

Human ADA protein (His Tag) - orb138126 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Baculovirus-Insect Cells Species Human

ADA Blocking Peptide - 33R-1257 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ADA Blocking Peptide - 33R-1412 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Adenosine Deaminase Protein - abx065150 from Abbexa Category Protein Source E.coli Species Human

Adenosine deaminase (1-363, His-tag) - AR39056PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

Adenosine deaminase (1-363, His-tag) - AR39056PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

Adenosine deaminase (ADA) - H00000100-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Adenosine deaminase (ADA) - H00000100-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Adenosine Deaminase, Human Recombinant - 228-12298-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Adenosine Deaminase Human - 228-12298-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Adenosine Deaminase Human - 228-12298-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

ADA, 1-363aa, Human, His tag, E.coli - 01-P1116 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

Adenosine Deaminase (ADA), Human - 20-7691 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

ADA fusion protein - ag4128 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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