MAPK1

Gene Symbol MAPK1
Entrez Gene 5594
Alt Symbol ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 1
Other Description MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2
Swissprots P28482 A8CZ64
Accessions ABF47102 ABY87541 AGC09596 CBK51146 EAW59479 EAW59480 EAW59481 EAW59482 P28482 AI004470 AK055080 AK057143 AK090869 AK295188 BAG58192 AK307615 BC017832 AAH17832 BC099905 AAH99905 BQ774391 DQ399292 ABD60303 EF565108 EU176323 ABW03774 EU831429 ACE87116 EU831522 ACE86441 Z11694 CAA77752 Z11695 CAA77753 NM_002745 NP_002736 NM_138957 NP_620407
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
Top Pathways TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

p42 MAP Kinase (Erk2) Antibody - 9108 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Fluorescein Conjugate) #6201 (-) or SignalSilence ® Pool p42 MAPK siRNA or single-duplex SignalSilence ® p42 MAPK siRNA (+), using p42 MAP Kinase (Erk2) Antibody #9108 and α-Tubulin (11H10) Rabbit mAb #2125. The p42 MAP Kinase (Erk2) Antibody confirms silencing of p42 expression and α-Tubulin (11H10) Rabbit mAb is used to control for loading and specificity of p42 siRNA.

ERK 1/2 (C-9) - sc-514302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 1/2 (C-9): sc-514302. Western blot analysis of ERK 1/2 expression in A-431 (A), HeLa (B), MCF7 (C), NIH/3T3 (D) and KNRK (E) whole cell lysates.

ERK 1/2 (H-72) - sc-292838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ERK 1 (G-12) - sc-376852 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 1 (G-12): sc-376852. Western blot analysis of ERK 1 expression in non-transfected 293T: sc-117752 (A), human ERK 1 transfected 293T: sc-171765 (B) and A-431 (C) whole cell lysates.

ERK 2 (C-8) - sc-271458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 2 (C-8): sc-271458. Western blot analysis of ERK 2 expression in HeLa whole cell lysate.

ERK 2 (H-9) - sc-271451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 2 (H-9): sc-271451. Western blot analysis of ERK 2 expression in HeLa whole cell lysate.

ERK 2 (C-14) - sc-154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERK 2 (C-14): sc-154. Western blot analysis of ERK 2 expression in A-431 (A), HeLa (B), KNRK (C), NIH/3T3 (D), NRK (E) and DU 145 (F) whole cell lysates.

ERK 2 (D-2) - sc-1647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of inactive (A,C,E) and active (B,D,F) rat recombinant ERK. Antibodies tested include ERK 2 (D-2): sc-1647 (A,B), p-ERK (Tyr 204): sc-7976 (C,D) and p-ERK (Tyr 204)-R: sc-7976-R (E,F).

ERK 2 (K-23) - sc-153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERK 2 (K-23): sc-153. Western blot analysis of ERK 1 and ERK 2 expression in HeLa (A), A-431 (B), KNRK (C) and NIH/3T3 (D) whole cell lysates.

ERK 2 (4C11C11C4) - sc-65981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 2 (4C11C11C4): sc-65981. Western blot analysis of ERK 2 expression in HeLa (A), A-431 (B) and DU 145 (C) whole cell lysates.

ERK 2 (6H3) - sc-81459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ERK 2 (6H3): sc-81459. Western blot analysis of ERK 2 expression in rat hippocampus tissue extract.

ERK 1/2 (MK1) - sc-135900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ERK 1/2 (MK1): sc-135900. Western blot analysis of ERK 1/2 expression in rat cerebrum tissue extract.

ERK 2 (12A4) - sc-81457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ERK 2 (12a4): sc-81457. Western blot analysis of ERK 2 expression in 293T (A) and A-431 (B) whole cell lysates.

ERK 2 (6G11) - sc-81458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ERK 2 (6G11): sc-81458. Western blot analysis of ERK 2 expression in 293T (A) and A-431 (B) whole cell lysates.

ERK 2 (33) - sc-136288 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
ERK 2 (33): sc-136288. Immunofluorescence staining of MCF7 cells showing cytoplasmic localization.

p-ERK 1/2 (pT202/pY204.22A) - sc-136521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-ERK 1/2 (12D4) - sc-81492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-ERK 1/2 (12D4): sc-81492. Western blot analysis of ERK 1/2 phosphorylation in non-stimulated (A), EGF stimulated (B) and pervanadate treated (C) SKOV3 whole cell lysates.

Anti-ERK1 + ERK2 (phospho T185 + Y187) antibody (Alexa Fluor® 488) - ab200807 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of NIH3T3 cells labeling ERK1 + ERK2 (phospho T185 + Y187) using ab200807 at 1/50 dilution. NIH3T3 cells were serum starved and either left untreated (left image) or treated with PDGF (50 ng/mL for 15 minutes) (right image).

Anti-ERK1 + ERK2 antibody - ab76163 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-ERK1 + ERK2 antibody - ab16573 from Abcam

Prices $370.00
Sizes 125 µg
Host Sheep
Clonality Polyclonal

Anti-ERK1 + ERK2 antibody - ab52245 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ERK1 + ERK2 antibody (ab52245) at 1/300 dilutionLane 1 : COLO205 cell extract; without peptideLane 2 : COLO205 cell extract; with peptide

Anti-ERK1 + ERK2 antibody [9B3] - ab36991 from Abcam

Prices $391.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9B3
All lanes : Anti-ERK1 + ERK2 antibody [9B3] (ab36991)Lane 1 : U87MG cell lysatesLane 2 : HepG2 cell lysatesLane 3 : Jurkat cell lysatesLane 4 : A431 cell lysates

Anti-ERK1 + ERK2 antibody [E31R] - ab127422 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone E31R
All lanes : Anti-ERK1 + ERK2 antibody [E31R] (ab127422) at 1/1000 dilutionLane 1 : HeLa cell lysate at 10 µgLane 2 : HeLa cell lysate at 30 µgdeveloped using the ECL technique

Anti-ERK1 + ERK2 antibody [EPR17526] - ab184699 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17526
Anti-ERK1 + ERK2 antibody [EPR17526] (ab184699) at 1/10000 dilution + Human ERK1 full length protein (ab43623) at 0.01 µgSecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-ERK1 + ERK2 antibody [IL-13] - ab130004 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone IL-13
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