MAPK1

Gene Symbol	MAPK1
Entrez Gene	5594
Alt Symbol	ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 1
Other Description	MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2
Swissprots	P28482 A8CZ64
Accessions	ABF47102 ABY87541 AGC09596 CBK51146 EAW59479 EAW59480 EAW59481 EAW59482 P28482 AI004470 AK055080 AK057143 AK090869 AK295188 BAG58192 AK307615 BC017832 AAH17832 BC099905 AAH99905 BQ774391 DQ399292 ABD60303 EF565108 EU176323 ABW03774 EU831429 ACE87116 EU831522 ACE86441 Z11694 CAA77752 Z11695 CAA77753 NM_002745 NP_002736 NM_138957 NP_620407
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location	Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
Top Pathways	TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p42 MAP Kinase (Erk2) siRNA I - 6540 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® p42 MAP Kinase (Erk2) siRNA II - 6578 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence® Pool p42 MAPK siRNA - 6391 from Cell Signaling Technology Category siRNA Species Reactivities Human, Monkey

ERK 2 CRISPR/Cas9 KO Plasmid (h) - sc-400043 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 HDR Plasmid (h) - sc-400043-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 Double Nickase Plasmid (h) - sc-400043-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 Double Nickase Plasmid (h2) - sc-400043-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 CRISPR Activation Plasmid (h) - sc-400043-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 CRISPR Activation Plasmid (h2) - sc-400043-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 Lentiviral Activation Particles (h) - sc-400043-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 Lentiviral Activation Particles (h2) - sc-400043-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 2 siRNA (h) - sc-35335 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 2 shRNA Plasmid (h) - sc-35335-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 2 shRNA (h) Lentiviral Particles - sc-35335-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 2 siRNA (h2) - sc-44223 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 2 shRNA Plasmid (h2) - sc-44223-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 2 shRNA (h2) Lentiviral Particles - sc-44223-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK2 RNAi - H00005594-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU044171 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1183 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1184 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1185 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2112 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2112 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MAPK1 siRNA (Human) - CRH3764 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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