| Gene Symbol | MAPK1 |
|---|---|
| Entrez Gene | 5594 |
| Alt Symbol | ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 1 |
| Other Description | MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2 |
| Swissprots | P28482 A8CZ64 |
| Accessions | ABF47102 ABY87541 AGC09596 CBK51146 EAW59479 EAW59480 EAW59481 EAW59482 P28482 AI004470 AK055080 AK057143 AK090869 AK295188 BAG58192 AK307615 BC017832 AAH17832 BC099905 AAH99905 BQ774391 DQ399292 ABD60303 EF565108 EU176323 ABW03774 EU831429 ACE87116 EU831522 ACE86441 Z11694 CAA77752 Z11695 CAA77753 NM_002745 NP_002736 NM_138957 NP_620407 |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel |
| Subcellular Location | Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}. |
| Top Pathways | TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion |