Trpm1

Gene Symbol Trpm1
Entrez Gene 17364
Alt Symbol 4732499L03Rik, AI606771, Ltrpc1, Mlsn1
Species Mouse
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 1
Other Description long transient receptor potential channel 1|melastatin-1|transient receptor potential cation channel subfamily M member 1
Swissprots Q640P5 Q3UEW7 Q3TPG5 Q2TV84 Q3UFV6 O70334 Q2WEA6 Q5U4B3 Q3UFW1 Q3UG69
Accessions Q2TV84 AF047714 AAC13683 AJ867481 CAI30140 AK044507 AK076406 AK148094 BAE28340 AK148193 AK148268 BAE28448 AK148275 BAE28453 AK149290 BAE28794 AK164395 BAE37771 AK164423 AK180567 AK181518 AK181524 AK183531 AK184260 AK184340 AK185201 AK188044 AK189982 AK190146 AK190156 AK190225 AK190255 AK190262 AK190274 AK190336 AK190415 AK190419 AK190432 AK190449 AK190526 AK190606 AK190619 AK190666 AK190667 AK190674 AK190698 AK190719 AK190766 AK190823 AK190840 AK190878 AK190970 AK190972 AK190979 AK191100 AK191136 AK191215 AK191287 AK191358 AK191386 AK191389 AK191442 AK191452 AK191453 AK191543 AK191553 AK191554 AK191608 AK191624 AK191665 AK191666 AK191673 AK191696 AK191720 AK191759 AK191761 AK191785 AK191840 AK191862 AK191908 AK191916 AK191940 AK191953 AK191972 AK192022 AK192027 AK192097 AK192132 AK192224 AK192245 AK192261 AK192270 AK192381 AK192483 AK192500 AK192510 AK192520 AK192577 AK192642 AK192749 AK192880 AK192969 AK192981 AK193000 AK193027 AK193110 AK193140 AK193189 AK193208 AK193242 AK193309 AK193326 AK193335 AK193404 AK193450 AK193478 AK193511 AK193514 AK193564 AK193599 AK193600 AK193677 AK193718 AK193726 AK193730 AK193745 AK193754 AK193802 AK193876 AK193879 AK193886 AK193904 AK193932 AK193962 AK193966 AK194011 AK194020 AK194046 AK194126 AK194130 AK194167 AK194252 AK194299 AK194310 AK194316 AK194355 AK194361 AK194374 AK194401 AK194412 AK194458 AK194644 AK194682 AK194766 AK194834 AK194863 AK194882 AK194934 AK195001 AK195005 AK195048 AK195051 AK195060 AK195072 AK195099 AK195136 AK195176 AK195245 AK195277 AK195281 AK195354 AK195430 AK195462 AK195552 AK195666 AK195668 AK195686 AK195734 AK195835 AK195888 AK195926 AK196034 AK196056 AK196100 AK196104 AK196125 AK196140 AK196151 AK196171 AK196200 AK196265 AK196331 AK196392 AK196403 AK196460 AK196486 AK196488 AK196566 AK196613 AK196628 AK196630 AK196664 AK196719 AK196825 AK196832 AK196850 AK196869 AK196905 AK196918 AK196976 AK196999 AK197227 AK197230 AK197263 AK197302 AK197366 AK197403 AK197432 AK197512 AK197532 AK197558 AK197574 AK197581 AK197584 AK197629 AK197654 AK197656 AK197678 AK197731 AK197757 AK197773 AK197822 AK197842 AK197866 AK197960 AK197979 AK197997 AK197999 AK198002 AK198047 AK198100 AK198120 AK198127 AK198148 AK198178 AK198239 AK198289 AK198294 AK198334 AK198336 AK198347 AK198366 AK198396 AK198455 AK198555 AK198563 AK198678 AK198682 AK198716 AK198734 AK198755 AK198807 AK198822 AK198830 AK198851 AK198856 AK198877 AK198919 AK198956 AK199086 AK199150 AK199181 AK199225 AK199238 AK199345 AK199374 AK199395 AK199411 AK199444 AK199586 AK199640 AK199680 AK199687 AK199734 AK199781 AK199794 AK199798 AK199874 AK199932 AK199999 AK200071 AK200123 AK200199 AK200209 AK200256 AK200424 AK200460 AK200613 AK200801 AK200831 AK200855 AK200915 AK201048 AK201152 AK201204 AK201408 AK201413 AK201492 AK201500 AK201503 AK201538 AK201566 AK201631 AK201639 AK201672 AK201676 AK201726 AK201763 AK201774 AK201786 AK201829 AK201839 AK201865 AK201913 AK201935 AK201983 AK201987 AK201989 AK202061 AK202065 AK202089 AK202116 AK202153 AK202157 AK202195 AK202246 AK202268 AK202303 AK202310 AK202317 AK202352 AK202393 AK202394 AK202423 AK202439 AK202483 AK202583 AK202595 AK202609 AK202622 AK202657 AK202672 AK202694 AK202705 AK202714 AK202830 AK202861 AK202865 AK202914 AK202929 AK202930 AK203038 AK203063 AK203065 AK203068 AK203129 AK203152 AK203258 AK203374 AK203401 AK203404 AK203415 AK203477 AK203591 AK203611 AK203638 AK203675 AK203767 AK203790 AK203858 AK203906 AK203960 AK203961 AK204027 AK204041 AK204100 AK204139 AK204262 AK204392 AK204508 AK204671 AK204694 AK204737 AK204748 AK204761 AK204917 AK204934 AK204991 AK205038 AK205104 AK205137 AK205189 AK205201 AK205296 AK205916 AK206340 AK208031 AK208032 AK208211 AK209093 AK209819 AK210029 AK210227 AK210425 AK210565 AK212032 AK212111 AK212724 AK212948 AK213026 AK214278 AK216151 AK216555 AK217026 AK217219 AK217312 AK217386 AK217880 AK217903 AK219280 AK219405 AK219645 AK219762 AY180104 AAO43093 BB763853 BC082560 AAH82560 BC085168 AAH85168 BC167220 AAI67220 BY100491 NM_001039104 NP_001034193 NM_018752 NP_061222
Function Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel. {ECO:0000269|PubMed:19861548, ECO:0000269|PubMed:19966281, ECO:0000269|PubMed:9537257}.
Subcellular Location Cell membrane {ECO:0000255, ECO:0000305}; Multi-pass membrane protein {ECO:0000255, ECO:0000305}.
Tissue Specificity Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic variants of B16 melanoma. {ECO:0000269|PubMed:19861548, ECO:0000269|PubMed:19966281, ECO:0000269|PubMed:9537257}.

Anti-TRPM1 antibody - ab63020 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM1 antibody - ab63121 from Abcam

Host Sheep
Clonality Polyclonal

TRPM1 Antibody - NB110-74925 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPM1 Antibody - NB110-74972 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

TRPM1 Polyclonal Antibody - OSR00049W from Thermo Fisher Scientific

Prices $309.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TRPM1 Antibody - OST00005W from Thermo Fisher Scientific

Prices $292.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-TRPM1 Antibody, clone 545H5 - MABN1841 from EMD Millipore

Prices $299.00
Sizes 100 μg
Host Mouse
Clonality Monoclonal
Clone 545H5

Anti-TRPM1 monoclonal antibody, clone 656I6 - CABT-B1352 from Creative Diagnostics

Host Mouse
Clonality Monoclonal
Clone 656I6

Anti-TRPM1 Antibody, clone 545H5 - MABN1841 from Sigma-Aldrich

Prices $299.00
Sizes mabn1841
Clonality Monoclonal
Western Blotting Analysis:<br />Representative lot data.<br />Proteins in mouse retina post-nuclear lysate were seperated by electrophoresis (~25 µg or ~0.3 retina equivalent per lane) without prior heating, transferred to nitrocellulose membrane, blocked with 5% milk in TBST, and probed with Cat. No. MABN1841, Anti-TRPM1, clone 545H5 (1 µg/mL) overnight at 4°C. Proteins were visualized using an anti-mouse IgG secondary antibody conjugated to HRP and a chemiluminescence detection system.<br />Arrow indicates TRPM1 (~180 kDa).<br />(Image courtesy of Dr. Melina A. Agosto, Baylor College of Medicine, Houston, TX)
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