AKR1C2

Gene Symbol	AKR1C2
Entrez Gene	1646
Alt Symbol	AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Species	Human
Gene Type	protein-coding
Description	aldo-keto reductase family 1, member C2
Other Description	3-alpha-HSD3|aldo-keto reductase family 1 member C2|chlordecone reductase homolog HAKRD|dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III|pseudo-chlordecone reductase|testicular 17,20-desmolase deficiency|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
Swissprots	Q96A71 Q14133 Q7M4N1 B4DKR9 A8K2N9 P52895 Q5SR16
Accessions	AAB38486 ABD36086 BAA92891 CAD88527 P52895 AB021654 BAA36169 AB031084 BAA92884 AB209017 BAD92254 AK091194 AK290304 BAF82993 AK296419 BAG59081 AK296686 BAG59281 AK308385 BC007024 AAH07024 BC063574 AAH63574 BT006653 AAP35299 CA450425 DA451165 DA458030 DQ890680 ABM81606 DQ893862 ABM84788 M33376 S68330 AAD14013 U05598 AAA20937 XM_011519342 XP_011517644 NM_001135241 NP_001128713 NM_001354 NP_001345 NM_205845 NP_995317
Function	Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.
Subcellular Location	Cytoplasm {ECO:0000305}.
Tissue Specificity	Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AKR1C2 Gene cDNA Clone - orb141733 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-AKR1C2-cDNA-Clone - DC08370 from Abgent, a WuXi AppTec company Prices $436.05 Sizes 10 µg Species Human Accession BC007024

AKR1C2 - MBS1277459 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC063574

AKR1C2 - MBS1266413 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007024

Human AKR1C2 ORF Clone(NM_001135241.2) - CDCL153517 from Creative Biomart Species Human Accession NM_001135241.2

Human AKR1C2 / DDH2 Gene ORF cDNA clone in cloning vector - HG14175-G from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14175-CY from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14175-NF from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14175-NM from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14175-CF from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14175-ACG from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14175-CM from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-His tag - HG14175-NH from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14175-ACR from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14175-ANR from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, C-His tag - HG14175-CH from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14175-NY from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14175-ANG from Sino Biological Species Human

Human AKR1C2 / DDH2 Gene ORF cDNA clone expression plasmid - HG14175-UT from Sino Biological Species Human

Human AKR1C2 ORF Clone (BC007024) - CDCS408076 from Creative biogene Species Human Accession P52895

Human AKR1C2 ORF Clone (BC063574) - CDCS408077 from Creative biogene Species Human Accession P52895

Human AKR1C2 ORF clone (BC007024) - CDCB159327 from Creative biogene Species Human

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