AKR1C2

Gene Symbol AKR1C2
Entrez Gene 1646
Alt Symbol AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member C2
Other Description 3-alpha-HSD3|aldo-keto reductase family 1 member C2|chlordecone reductase homolog HAKRD|dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III|pseudo-chlordecone reductase|testicular 17,20-desmolase deficiency|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase|type II dihydrodiol dehydrogenase
Swissprots Q96A71 Q14133 Q7M4N1 B4DKR9 A8K2N9 P52895 Q5SR16
Accessions AAB38486 ABD36086 BAA92891 CAD88527 P52895 AB021654 BAA36169 AB031084 BAA92884 AB209017 BAD92254 AK091194 AK290304 BAF82993 AK296419 BAG59081 AK296686 BAG59281 AK308385 BC007024 AAH07024 BC063574 AAH63574 BT006653 AAP35299 CA450425 DA451165 DA458030 DQ890680 ABM81606 DQ893862 ABM84788 M33376 S68330 AAD14013 U05598 AAA20937 XM_011519342 XP_011517644 NM_001135241 NP_001128713 NM_001354 NP_001345 NM_205845 NP_995317
Function Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. {ECO:0000269|PubMed:15929998, ECO:0000269|PubMed:17034817, ECO:0000269|PubMed:17442338, ECO:0000269|PubMed:8573067}.
Subcellular Location Cytoplasm {ECO:0000305}.
Tissue Specificity Expressed in fetal testes. Expressed in fetal and adult adrenal glands. {ECO:0000269|PubMed:21802064}.
Top Pathways Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

DD2 CRISPR/Cas9 KO Plasmid (h) - sc-417677 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 HDR Plasmid (h) - sc-417677-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 Double Nickase Plasmid (h) - sc-417677-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 Double Nickase Plasmid (h2) - sc-417677-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 CRISPR Activation Plasmid (h) - sc-417677-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 CRISPR Activation Plasmid (h2) - sc-417677-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 Lentiviral Activation Particles (h) - sc-417677-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 Lentiviral Activation Particles (h2) - sc-417677-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DD2 siRNA (h) - sc-106922 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DD2 shRNA Plasmid (h) - sc-106922-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DD2 shRNA (h) Lentiviral Particles - sc-106922-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AKR1C2 RNAi - H00001646-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU107701 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU148491 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3027 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3027 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01421 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01421

AKR1C2 siRNA (Human) - CRH1160 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AKR1C2 RNAi - H00001646-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

AKR1C2 - MBS8241287 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human AKR1C2 siRNA - orb261662 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AKR1C2 shRNA Plasmid (Human) - CHH1160 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AKR1C2 miRNA 3'UTR clone - MiUTR3H-03386 from Creative biogene

Species Reactivities Human

AKR1C2 miRNA 3'UTR clone - MiUTR3H-03387 from Creative biogene

Species Reactivities Human

AKR1C2 miRNA 3'UTR clone - MiUTR3H-03388 from Creative biogene

Species Reactivities Human
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