| Gene Symbol | Slit2 |
|---|---|
| Entrez Gene | 360272 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | slit homolog 2 (Drosophila) |
| Other Description | slit homolog 2 protein|slit-2 |
| Swissprots | Q9WVC1 |
| Accessions | EDL99919 Q9WVC1 XM_008770210 XP_008768432 NM_022632 NP_072154 |
| Function | Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth- stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post- crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for |
| Subcellular Location | Secreted {ECO:0000250}. |
| Top Pathways | Axon guidance |
Anti-Slit Homolog 2 (Slit2) - 20-3013 from ARP American Research Products
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Slit Homolog 2 (Slit2), Polyclonal Antibody - MBS2002144 from MyBioSource
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