ERO1L

Gene Symbol	ERO1L
Entrez Gene	30001
Alt Symbol	ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1A, ERO1LA
Species	Human
Gene Type	protein-coding
Description	ERO1-like (S. cerevisiae)
Other Description	ERO1-like protein alpha|endoplasmic oxidoreductin-1-like protein|oxidoreductin-1-L-alpha
Swissprots	Q7LD45 Q9P1Q9 A8MYW1 A8K9X4 Q9UKV6 Q96HE7
Accessions	EAW65646 EAW65647 Q96HE7 AF081886 AAF35260 AF123887 AAF06104 AK024224 AK292839 BAF85528 AY358463 AAQ88828 BC008674 AAH08674 BC012941 AAH12941 BX420309 CR990477 DR006292 GQ129372 ACT64506 GQ129373 ACT64507 HQ448296 ADQ32776 JF432168 ADZ15385 XM_011536684 XP_011534986 NM_014584 NP_055399
Function	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.
Tissue Specificity	Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}.
Top Pathways	Vibrio cholerae infection, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ERO1L full length protein - ab132625 from Abcam Category Protein Source Wheat germ Species Human

Human ERO1L full length protein - ab180283 from Abcam Category Protein Source E. coli Species Human

Human ERO1L protein fragment - ab125981 from Abcam Category Protein Source E. coli Species Human

ERO1A / ERO1L Antibody Blocking Peptide - LS-E2341 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERO1A / ERO1L Antibody Blocking Peptide - LS-E27670 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERO1L Partial Recombinant Protein - H00030001-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERO1L Recombinant Protein - H00030001-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERO1L-Antibody-C-term-Blocking-peptide - BP13305b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPO1L protein (His tag) - 80R-3802 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

ERO1L Peptide - AC21-2488-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ERO1L (24-468, His-tag) - AR51489PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

ERO1L (24-468, His-tag) - AR51489PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

ERO1L - H00030001-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ERO1L - H00030001-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ERO1L - H00030001-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ERO1L - H00030001-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EPO1L, 24-468aa, Human, His tag, E.coli - 01-P2669 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ERO1L Peptide - 42-847P from ProSci Category Peptide Species Human

ERO1L fusion protein - ag2620 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ERO1L, His-tagged - ERO1L-82H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human ERO1-like protein alpha(ERO1L) - CSB-YP846631HU CSB-EP846631HU CSB-BP846631HU CSB-MP846631HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EPO1L, 24-468aa, Human, His tag, E.coli - ATGP2669 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ERO1L Protein - abx163935 from Abbexa Category Protein Species Human

ERO1L - TP303840 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ERO1-like, Peptide - MBS427480 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

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