ERO1L

Gene Symbol ERO1L
Entrez Gene 30001
Alt Symbol ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1A, ERO1LA
Species Human
Gene Type protein-coding
Description ERO1-like (S. cerevisiae)
Other Description ERO1-like protein alpha|endoplasmic oxidoreductin-1-like protein|oxidoreductin-1-L-alpha
Swissprots Q7LD45 Q9P1Q9 A8MYW1 A8K9X4 Q9UKV6 Q96HE7
Accessions EAW65646 EAW65647 Q96HE7 AF081886 AAF35260 AF123887 AAF06104 AK024224 AK292839 BAF85528 AY358463 AAQ88828 BC008674 AAH08674 BC012941 AAH12941 BX420309 CR990477 DR006292 GQ129372 ACT64506 GQ129373 ACT64507 HQ448296 ADQ32776 JF432168 ADZ15385 XM_011536684 XP_011534986 NM_014584 NP_055399
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.
Tissue Specificity Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}.
Top Pathways Vibrio cholerae infection, Protein processing in endoplasmic reticulum

Ero1-Lα CRISPR/Cas9 KO Plasmid (h) - sc-401747 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα HDR Plasmid (h) - sc-401747-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα Double Nickase Plasmid (h) - sc-401747-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα Double Nickase Plasmid (h2) - sc-401747-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα CRISPR Activation Plasmid (h) - sc-401747-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα CRISPR Activation Plasmid (h2) - sc-401747-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα Lentiviral Activation Particles (h) - sc-401747-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα Lentiviral Activation Particles (h2) - sc-401747-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ero1-Lα siRNA (h) - sc-77284 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ero1-Lα shRNA Plasmid (h) - sc-77284-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ero1-Lα shRNA (h) Lentiviral Particles - sc-77284-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERO1L RNAi - H00030001-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU085061 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7973 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7973 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10408 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10408

ERO1L siRNA (Human) - CRH9329 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ERO1L - MBS8200277 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ERO1L (NM_014584.1) - SHH287205 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ERO1L(NM_014584.1) - SHH039125 from Creative biogene

Category siRNA
Species Reactivities Human

Human ERO1L siRNA - orb269831 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ERO1L shRNA Plasmid (Human) - CHH9329 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ERO1L miRNA 3'UTR clone - MiUTR1H-03304 from Creative biogene

Species Reactivities Human
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