BCL2

Gene Symbol BCL2
Entrez Gene 596
Alt Symbol Bcl-2, PPP1R50
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 2
Other Description apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
Swissprots Q13842 Q16197 C9JHD5 P10416 P10415
Accessions AAD14111 AAO26045 CAR95111 CAR95112 CCA94580 CDM22285 CDM22286 EAW63136 EAW63137 EAW63138 EAW63139 P10415 AF401211 AAL02169 AI401297 BC027258 AAH27258 DQ891470 ABM82396 DQ894654 ABM85580 EU287875 ABX60202 M13994 AAA51813 M13995 AAA51814 M14745 AAA35591 X06487 CAA29778 XM_011526135 XP_011524437 XR_935246 XR_935247 XR_935248 NM_000633 NP_000624 NM_000657 NP_000648
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269|PubMed:18570871}.
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}.
Tissue Specificity Expressed in a variety of tissues.
Top Pathways Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway

Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 2834 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone 5H2
Flow cytometric analysis of Jurkat cells, untreated (upper) or paclitaxel-treated (lower), using Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (Alexa Fluor ® 488 Conjugate) versus propidium iodide (DNA content). The blue inserts represent propidium iodide staining alone, showing cells in mitotic arrest in the paclitaxel-treated sample.

Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb - 2827 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 5H2
Western blot analysis of extracts from Jurkat cells, untreated or treated with paclitaxel (1 μM, overnight) and with or without λ phosphatase, using Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb (upper) or Bcl-2 #2876 (lower).

Phospho-Bcl-2 (Thr56) Antibody (Human Specific) - 2875 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Jurkat cells, untreated or treated with pacilitaxel for the indicated times, using Phospho-Bcl-2 (Thr56) Antibody (Human Specific) (top) or Bcl-2 Antibody (Human Specific) #2872 (bottom).

Bcl-2 (D17C4) Rabbit mAb (Mouse Preferred) - 3498 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D17C4
Western blot analysis of extracts from various cell lines using Bcl-2 (D17C4) Rabbit mAb (Mouse Preferred).

Bcl-2 Antibody (Human Specific) - 2872 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat and THP-1 cells using Bcl-2 Antibody (Human Specific).

Bcl-2 (50E3) Rabbit mAb - 2870 from Cell Signaling Technology

Prices $99.00, $249.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 50E3
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence® Control siRNA (Fluorescein Conjugate) #6201 (-), SignalSilence® Bcl-2 siRNA I (+) or SignalSilence® Bcl-2 siRNA II #6516 (+), using Bcl-2 (50E3) Rabbit mAb and α-Tubulin (11H10) Rabbit mAb #2125. Bcl-2 (50E3) Rabbit mAb #2870 confirms silencing of Bcl-2 expression, while the α-tubulin (11H10) rabbit mAb is used to control for loading and specificity of Bcl-2 siRNA.

Bcl-2 (D55G8) Rabbit mAb (Human Specific) - 4223 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D55G8
Western blot analysis of extracts from various cell lines using Bcl-2 (D55G8) Rabbit mAb (Human Specific).

Bcl-2 Antibody - 2876 from Cell Signaling Technology

Prices $99.00, $239.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa (human), CTLL-2 (mouse), and PC12 (rat) cells, using Bcl-2 Antibody.

Phospho-Bcl-2 (Ser70) Antibody (Human Specific) - 2871 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Bcl-2 (N-19) - sc-492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Bcl-2 expression in U-937 (A,D), HL-60 (B,E) and Jurkat (C,F) whole cell lysates. Antibodies tested include Bcl-2 (100): sc-509 (A-C) and Bcl-2 (N-19): sc-492 (D-F).

Bcl-2 (C-2) - sc-7382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (C-2) PE: sc-7382 PE. Intracellular FCM analysis of fixed and permeabilized Jurkat cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

Bcl-2 (100) - sc-509 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bcl-2 expression in U-937 (A,D), HL-60 (B,E) and Jurkat (C,F) whole cell lysates. Antibodies tested include Bcl-2 (100): sc-509 (A-C) and Bcl-2 (N-19): sc-492 (D-F).

Bcl-2 (C 21) - sc-783 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-2 (ΔC 21): sc-783. Western blot analysis of Bcl-2 expression in HL-60 (A) and Jurkat (B) whole cell lysates.

Bcl-2 (7) - sc-130308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (7): sc-130308. Western blot analysis of Bcl-2 expression in HL-60 (A), U-937 (B) and Jurkat (C) whole cell lysates.

Bcl-2 (12) - sc-130307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (12): sc-130307. Western blot analysis of Bcl-2 expression in HL-60 whole cell lysate.

Bcl-2 (100/D5) - sc-56015 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (100/D5): sc-56015. Western blot analysis of Bcl-2 expression in U-937 (A), HL-60 (B), Jurkat (C) and U-698-M (D) whole cell lysates.

Bcl-2 (8C8) - sc-65392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (8C8): sc-65392. Western blot analysis of Bcl-2 expression in U-937 (A) and HL-60 (B) whole cell lysates.

Bcl-2 (SPM117) - sc-56018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-2 (SPM117): sc-56018. Western blot analysis of Bcl-2 expression in U-937 (A), HL-60 (B) and Jurkat (C) whole cell lysates.

p-Bcl-2 (A-3) - sc-377513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), human recombinant ERK 2 treated (B,E) and human recombinant ERK 2 and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant Bcl-2 fusion proteins. Antibodies tested include p-Bcl-2 (A-3): sc-377513 (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).

p-Bcl-2 (Ser 87) - sc-16323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), human recombinant p38α treated (B,E) and human recombinant p38α and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant Bcl-2 fusion proteins. Antibodies tested include p-p-Bcl-2 (Ser 87)-R: sc-16323-R (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).

p-Bcl-2 (A-11) - sc-377554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), ERK2 treated (B,E) and ERK2 and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant Bcl-2. Antibodies tested include p-Bcl-2 (A-11): sc-377554. (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).

p-Bcl-2 (C-2) - sc-377576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,C), human recombinant p38 treated (B,D) human recombinant Bcl-2 fusion proteins. Antibodies tested include p-Bcl-2 (C-2): sc-377576 (A,B) and Bcl-2 (C-2): sc-7382 (C,D).

p-Bcl-2 (Thr 74) - sc-16322 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), human recombinant p38α treated (B,E) and human recombinant p38α and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant Bcl-2 fusion proteins. Antibodies tested include p-Bcl-2 (Thr 74)-R: sc-16322-R (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).

p-Bcl-2 (662.Ser 70) - sc-293129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), paclitaxel treated (B,E) and paclitaxel and lambda protein phosphatase (sc-200312A) treated (C,F) Jurkat whole cell lysates. Antibodies tested include p-Bcl-2 (662.Ser 70): sc-293129 (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).

p-Bcl-2 (Thr 56) - sc-16321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Bcl-2 phosphorylation in untreated (A,D), human recombinant p38α treated (B,E) and human recombinant p38α and lambda protein phosphatase (sc-200312A) treated (C,F) human recombinant Bcl-2 fusion proteins. Antibodies tested include p-Bcl-2 (Thr 56)-R: sc-16321-R (A,B,C) and Bcl-2 (C-2): sc-7382 (D,E,F).
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