BCL2

Gene Symbol	BCL2
Entrez Gene	596
Alt Symbol	Bcl-2, PPP1R50
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 2
Other Description	apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
Swissprots	Q13842 Q16197 C9JHD5 P10416 P10415
Accessions	AAD14111 AAO26045 CAR95111 CAR95112 CCA94580 CDM22285 CDM22286 EAW63136 EAW63137 EAW63138 EAW63139 P10415 AF401211 AAL02169 AI401297 BC027258 AAH27258 DQ891470 ABM82396 DQ894654 ABM85580 EU287875 ABX60202 M13994 AAA51813 M13995 AAA51814 M14745 AAA35591 X06487 CAA29778 XM_011526135 XP_011524437 XR_935246 XR_935247 XR_935248 NM_000633 NP_000624 NM_000657 NP_000648
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269|PubMed:18570871}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}.
Tissue Specificity	Expressed in a variety of tissues.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Bcl-2 siRNA I - 6441 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Bcl-2 siRNA II - 6516 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Bcl-2 CRISPR/Cas9 KO Plasmid (h) - sc-400025 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 HDR Plasmid (h) - sc-400025-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 Double Nickase Plasmid (h) - sc-400025-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 Double Nickase Plasmid (h2) - sc-400025-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 CRISPR Activation Plasmid (h) - sc-400025-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 CRISPR Activation Plasmid (h2) - sc-400025-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 Lentiviral Activation Particles (h) - sc-400025-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 Lentiviral Activation Particles (h2) - sc-400025-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bcl-2 siRNA (h) - sc-29214 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 shRNA Plasmid (h) - sc-29214-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 shRNA (h) Lentiviral Particles - sc-29214-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 siRNA (h2) - sc-61899 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 shRNA Plasmid (h2) - sc-61899-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 shRNA (h2) Lentiviral Particles - sc-61899-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bcl-2 RNAi - H00000596-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Bcl-2 RNAi - H00000596-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU135281 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1007 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1007 from Sigma-Aldrich Category ZFN Kit Prices $4,120.00 Sizes 1 kt

BCL2 siRNA (Human) - CRH0409 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BCL2 - MBS8200103 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BCL2 (NM_000633.2) - SHH245882 from Creative biogene Category siRNA Species Reactivities Human

Bcl-2 CRISPR/Cas9 KO Plasmid (h2) - sc-400025-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

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