S100a8

Gene Symbol	S100a8
Entrez Gene	20201
Alt Symbol	60B8Ag, AI323541, B8Ag, CFAg, CP-10, Caga, MRP8, p8
Species	Mouse
Gene Type	protein-coding
Description	S100 calcium binding protein A8 (calgranulin A)
Other Description	MRP-8|S100 calcium-binding protein A8|calgranulin-A|chemotactic S100 protein|chemotactic cytokine CP-10|leukocyte L1 complex light chain|migration inhibitory factor-related protein 8|pro-inflammatory S100 cytokine|protein S100-A8
Swissprots	P27005 P31724
Accessions	AAL40132 CAA61204 EDL15111 P27005 AK157837 BAE34219 AV007095 BC078629 AAH78629 M83218 AAB07229 S57123 AAB25840 Y09039 NM_013650 NP_038678
Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and
Subcellular Location	Secreted {ECO:0000269|PubMed:17767165}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Cytotoxin-associated protein (CagA) antibody (IgG), Mouse, ELISA Kit - E03C1310 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cytotoxin-associated protein (CagA), Mouse, ELISA Kit - E03C1309 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Protein S100-A8, S100a8, Mouse, ELISA Kit - E1792m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

S100 Calcium Binding Protein A8 (S100A8), Mouse, ELISA Kit - SEB792Mu from ARP American Research Products Category ELISA Kit Prices $704.00 Sizes 96 t Sensitivity 3.5pg/mL Range 7.8-500pg/mL

Mouse S100A8 ELISA Kit - MS0045 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

S100 calcium binding protein A8, ELISA Kit - MBS914449 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.156 ng/ml Range 0.625 ng/ml-40 ng/ml

Mouse/Rat S100A8 / S100A9 ELISA Kit - DEIA2176 from Creative Diagnostics Category ELISA Kit Sensitivity The analytical sensitivity (LLOD) of the Mouse/Rat S100A8 / S100A9 ELISA Kit as determined by the 95% confidence limit on 12 duplicate determination of zero standard is approximately 2.5 ng/mL A LLOQ was determined by dilution of assay standards and it is

Mouse S100A8(S100 Calcium Binding Protein A8) ELISA Kit - E-EL-M1343 from Elabscience Category ELISA Kit Sensitivity 0.38 ng/mL Range 0.63—40 ng/mL

Mouse S100A8 (S100 Calcium Binding Protein A8) CLIA Kit - E-CL-M0699 from Elabscience Category CLIA Kit Sensitivity 75.00 pg/mL Range Average Recovery (%)

Mouse S100 calcium binding protein A8 (S100A8) ELISA kit - CSB-EL020641MO from Cusabio Category ELISA Kit Sensitivity 0.156 ng/ml Range 0.625 ng/ml-40 ng/ml

Mouse S100 Calcium Binding Protein A8 ELISA - E03S0038 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for S100 Calcium Binding Protein A8 (S100A8) - SEB792Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 3.3pg/mL. Range 7.813-500pg/mL The standard curve concentrations used for the ELISA's were 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL, 7.813pg/mL

Mouse S100A8 (S100 Calcium Binding Protein A8) CLIA Kit - E-CL-M0699 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.375ng/mL Range 0.625-40ng/mL

Mouse S100A8 ELISA Kit - abx154632 from Abbexa Category ELISA Kit Range 7.81 pg/ml - 500 pg/ml

S100 Calcium Binding Protein A8 (S100A8), Mouse, ELISA Kit - DL-S100A8-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.625-40 ng/mL

Mouse S100A8 PicoKine™ ELISA Kit EK1150 - EK1150 from Boster Bio Category ELISA Kit Prices $333.00 Sizes 1 kit Sensitivity <10pg/ml Range 31.2pg/ml-2000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Mouse/Rat S100A8/S100A9 ELISA Kit - DEIA2176F from Creative Diagnostics Category ELISA Kit Sensitivity 0.076 ng/mL Range 0.25 - 15.6 ng/mL

Mouse S100A8 ELISA Kit - orb368280 from Biorbyt Category ELISA Kit Prices $544.00, $612.00 Sizes 48 test, 96 test Range Detection Range: 7.813-500pg/mL Detection low threshold: 3.5pg/mL

Mouse S100A8 ELISA Kit - abx576207 from Abbexa Category ELISA Kit Sensitivity 3.5 pg/ml Range 7.813 pg/ml - 500 pg/ml

S100A8 - EKM1354 from Nordic BioSite Sensitivity 0.375ng/ml Range 0.625-40ng/ml

Mouse MRP8 ELISA Kit - CEK1951 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 31.2 pg/ml - 2000 pg/ml

Mouse S100A8 ELISA Kit - orb385399 from Biorbyt Category ELISA Kit Prices $731.00 Sizes 96 test Sensitivity 10 pg/ml Range 31.2 pg/ml-2000 pg/ml

Mouse CagA ELISA Kit - E050489 from Biobool Category ELISA Kit

Mouse S100a8 ELISA Kit - E066911 from Biobool Category ELISA Kit Sensitivity 0.156 ng/ml

S100A8 ELISA Kit (Mouse) (OKEH03410) - OKEH03410 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity 0.3125 ng/mL Range 0.625 - 40 ng/mL

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