S100a8

Gene Symbol	S100a8
Entrez Gene	20201
Alt Symbol	60B8Ag, AI323541, B8Ag, CFAg, CP-10, Caga, MRP8, p8
Species	Mouse
Gene Type	protein-coding
Description	S100 calcium binding protein A8 (calgranulin A)
Other Description	MRP-8|S100 calcium-binding protein A8|calgranulin-A|chemotactic S100 protein|chemotactic cytokine CP-10|leukocyte L1 complex light chain|migration inhibitory factor-related protein 8|pro-inflammatory S100 cytokine|protein S100-A8
Swissprots	P27005 P31724
Accessions	AAL40132 CAA61204 EDL15111 P27005 AK157837 BAE34219 AV007095 BC078629 AAH78629 M83218 AAB07229 S57123 AAB25840 Y09039 NM_013650 NP_038678
Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and
Subcellular Location	Secreted {ECO:0000269|PubMed:17767165}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Recombinant Mouse S100A8 Protein - NBP1-72331 from Novus Biologicals Category Protein Prices $299.00, $729.00 Sizes 100 µg, 500 µg Source E. coli

S100A8 Recombinant Protein - P4345 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Mouse

Mouse S100A8 protein (His Tag) - orb139619 from Biorbyt Category Protein Prices $357.00, $527.00 Sizes 50 μg, 100 μg Source E. coli Species Mouse

Mouse S100a8 protein - orb244515 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

Mouse S100a8 protein - orb246785 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

S100A8 protein (His tag) - 80R-1841 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

Mouse S100A8 Protein - abx068973 from Abbexa Category Protein Source E.coli Species Mouse

S100A8 / Calgranulin-A / MRP8 (1-89, His-tag) - AR39025PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Mouse

S100A8 / Calgranulin-A / MRP8 (1-89, His-tag) - AR39025PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Mouse

S100A8 / Calgranulin-A / MRP8 - P4345 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Mouse

S100 Calcium Binding Protein A8 (S100A8), Mouse - 20-8019 from ARP American Research Products Category Protein Prices $419.00 Sizes 50 µg Source E.coli Species Mouse

S100A8, 1-89aa, Mouse,His tag, E.coli - 01-2081A8M from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Mouse

S100A8 Mouse - PRPS-240 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Mouse

Recombinant Mouse S100 Calcium Binding Protein A8 - BP001854-PRO-233 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Mouse

S100A8, 1-89aa, Recombinant Protein - GWB-P0953D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Mouse

Recombinant Mouse S100a8, His tagged - S100a8-405M from Creative Biomart Category Protein Source E. coli Species Mouse

Recombinant Mouse S100a8, His-tagged - S100a8-3545M from Creative Biomart Category Protein Source E. coli.

Recombinant Mouse S100 Calcium Binding Protein A8 (calgranulin A), His-tagged - S100a8-5107M from Creative Biomart Category Protein Source Mouse

S100A8 1-89aa - CMB-918 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Mouse

Mouse S100A8 / CAGA Protein (His Tag) - 50228-M07E-50 from Sino Biological Category Protein Prices $158.00, $248.00 Sizes 50 µg, 100 µg Source E. coli Species Mouse

Recombinant S100 Calcium Binding Protein A8 (S100A8) - RPB792Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant S100 Calcium Binding Protein A8 (S100A8) - RPB792Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Protein S100-A8(S100a8) - CSB-YP020641MO CSB-BP020641MO CSB-MP020641MO from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Mouse

Recombinant Mouse Protein S100-A8(S100a8) - CSB-EP020641MO from Cusabio Category Protein Source Yeast Species Mouse

S100A8, 1-89aa, Mouse,His tag, E.coli - ATGP1085 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Mouse

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