YWHAQ

Gene Symbol YWHAQ
Entrez Gene 10971
Alt Symbol 14-3-3, 1C5, HS1
Species Human
Gene Type protein-coding
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Other Description 14-3-3 protein T-cell|14-3-3 protein tau|14-3-3 protein theta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Swissprots Q9UP48 D6W4Z5 P27348 Q5TZU8 Q567U5
Accessions AAX93143 AAY24326 CAJ42708 EAX00977 EAX00978 EAX00979 P27348 AA729400 AF070556 AAC28640 AK297624 BAG60000 AK302208 BAG63566 AK309462 AK316158 BAH14529 AM393330 CAL38208 AM393338 CAL38216 AM393358 CAL38236 AM393674 CAL38550 BC001197 BC050601 AAH50601 BC056867 AAH56867 BC093019 AAH93019 BT020014 AAV38817 HY044745 X56468 CAA39840 X57347 CAA40622 NM_006826 NP_006817
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
Subcellular Location Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
Tissue Specificity Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269|PubMed:11080204}.
Top Pathways Cell cycle, Pathogenic Escherichia coli infection, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway

14-3-3 (pan) Antibody - 8312 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using 14-3-3 (pan) Antibody.

14-3-3 τ Antibody - 9638 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3, and C6 cells using 14-3-3 τ Antibody.

14-3-3 θ (C-17) - sc-732 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
14-3-3 θ (C-17): sc-732. Immunofluorescence staining of methanol-fixed A-431 cells showing cytoplasmic staining.

14-3-3 θ (3B9) - sc-59414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
14-3-3 θ (3B9): sc-59414. Western blot analysis of 14-3-3 θ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 θ transfected 293T: sc-116633 (B) and NIH/3T3 (C) whole cell lysates.

14-3-3 θ (5J20) - sc-69720 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
14-3-3 θ (5J20): sc-69720. Western blot analysis of 14-3-3 θ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 θ transfected 293T: sc-116633 (B) and NIH/3T3 (C) whole cell lysates.

Anti-14-3-3 Tau (phospho S232) antibody - ab63369 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab63369 at 1/500 dilution staining 14-3-3 Tau in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-14-3-3 Tau antibody - ab63630 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells using ab63630 at a dilution of 1/500-1/1000. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-14-3-3 Tau antibody - ab64991 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 Tau antibody (ab64991) at 1/500 dilutionLane 1 : Extracts from HUVEC cells at 5-30ug with no immunizing peptideLane 2 : Extracts from HeLa cells at 5-30ug with no immunizing peptideLane 3 : Extracts from HeLa cells at 5-30ug with immunizing peptide at 5-10ug

Anti-14-3-3 Tau antibody [AT1A1] - ab105326 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AT1A1
ab105326, at 10 µg/ml, staining 14-3-3 Tau in formalin-fixed, paraffin-embedded Human Brain, Cortex by Immunohistochemistry, using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-14-3-3 Theta + Tau antibody [EPR5123] - ab124909 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5123
All lanes : Anti-14-3-3 Theta + Tau antibody [EPR5123] (ab124909) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : 293T cell lysateLane 3 : A549 cell lysateLane 4 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-14-3-3 theta antibody - ab168855 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 theta antibody (ab168855) at 2 µg/mlLane 1 : Human brain tissue lysateLane 2 : Human brain tissue lysate in the presence of immunizing peptideLane 3 : A375 cell lysate

Anti-YWHAQ / 14-3-3 Theta Antibody (Azide-free) - LS-C34758 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-YWHAQ / 14-3-3 Theta Antibody - LS-C34772 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-YWHAQ / 14-3-3 Theta Antibody (N-Terminus) - LS-C42376 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-YWHAQ / 14-3-3 Theta Antibody (aa1-10) - LS-C121322 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-YWHAQ / 14-3-3 Theta Antibody (aa136-146) - LS-C54425 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.03 ug/ml) staining of Human Brain (Hippocampus) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-YWHAQ / 14-3-3 Theta Antibody (clone 33A) - LS-C193556 from LifeSpan Bioscience

Prices $905.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 33A

Anti-YWHAQ / 14-3-3 Theta Antibody (Trp228) - LS-C176632 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of 14-3-3 / (W228) pAb in extracts from HeLa cells.

Anti-YWHAQ / 14-3-3 Theta Antibody - LS-C26571 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
At right is a typical western blot (10% SDS-PAGE) of 3T3 (lane 1), PC12 (lane 2), MDBK (lane 3), Jurkat (lane 4) and normal human fibroblasts (lane 5).

Anti-YWHAQ / 14-3-3 Theta Antibody (aa196-245) - LS-C117785 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using 14-3-3 theta/tau (Ab-232) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-YWHAQ / 14-3-3 Theta Antibody (aa41-90) - LS-C119363 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HUVEC/HeLa cells, using 14-3-3 theta Antibody. The lane on the right is treated with the synthesized peptide.

Anti-YWHAQ / 14-3-3 Theta Antibody (phospho-Ser232) - LS-C291155 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-YWHAQ / 14-3-3 Theta Antibody (Biotin) - LS-C343170 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-YWHAQ / 14-3-3 Theta Antibody - LS-C343171 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-YWHAQ / 14-3-3 Theta Antibody (aa195-245) - LS-C289845 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human 14-3-3-theta by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-14-3-3-theta used at a dilution of 1:5000 (0.2 ug/ml). Detection: DAB.
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