| Gene Symbol |
YWHAQ
|
| Entrez Gene |
10971
|
| Alt Symbol |
14-3-3, 1C5, HS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
|
| Other Description |
14-3-3 protein T-cell|14-3-3 protein tau|14-3-3 protein theta|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
|
| Swissprots |
Q9UP48 D6W4Z5 P27348 Q5TZU8 Q567U5
|
| Accessions |
AAX93143 AAY24326 CAJ42708 EAX00977 EAX00978 EAX00979 P27348 AA729400 AF070556 AAC28640 AK297624 BAG60000 AK302208 BAG63566 AK309462 AK316158 BAH14529 AM393330 CAL38208 AM393338 CAL38216 AM393358 CAL38236 AM393674 CAL38550 BC001197 BC050601 AAH50601 BC056867 AAH56867 BC093019 AAH93019 BT020014 AAV38817 HY044745 X56468 CAA39840 X57347 CAA40622 NM_006826 NP_006817
|
| Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.
|
| Subcellular Location |
Cytoplasm. Note=In neurons, axonally transported to the nerve terminals.
|
| Tissue Specificity |
Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement. {ECO:0000269|PubMed:11080204}.
|
| Top Pathways |
Cell cycle, Pathogenic Escherichia coli infection, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway
|
![Western Blot: 14-3-3 tau/theta Overexpression Lysate (Adult Normal) [NBL1-17951] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for 14-3-3 tau/theta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5502_14-3-3%2520tau-theta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17951-img0002.jpg)