| Gene Symbol |
Cops3
|
| Entrez Gene |
26572
|
| Alt Symbol |
Csn3, Sgn3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana)
|
| Other Description |
COP9 (constitutive photomorphogenic), subunit 3|COP9 complex S3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3
|
| Swissprots |
O88543
|
| Accessions |
O88543 AF071313 AAC33900 AK048906 BAC33487 AK142318 BAE25027 AK169747 BAE41343 BC068179 AAH68179 XM_006533382 XP_006533445 XM_006533383 XP_006533446 NM_011991 NP_036121
|
| Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo. {ECO:0000269|PubMed:12972600}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12972600}.
|