Gene Symbol | Cops3 |
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Entrez Gene | 26572 |
Alt Symbol | Csn3, Sgn3 |
Species | Mouse |
Gene Type | protein-coding |
Description | COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) |
Other Description | COP9 (constitutive photomorphogenic), subunit 3|COP9 complex S3|COP9 signalosome complex subunit 3|JAB1-containing signalosome subunit 3|signalosome subunit 3 |
Swissprots | O88543 |
Accessions | O88543 AF071313 AAC33900 AK048906 BAC33487 AK142318 BAE25027 AK169747 BAE41343 BC068179 AAH68179 XM_006533382 XP_006533445 XM_006533383 XP_006533446 NM_011991 NP_036121 |
Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo. {ECO:0000269|PubMed:12972600}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12972600}. |
CSN3 CRISPR/Cas9 KO Plasmid (m) - sc-424105 from Santa Cruz Biotechnology
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CSN3 HDR Plasmid (m) - sc-424105-HDR from Santa Cruz Biotechnology
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CSN3 Double Nickase Plasmid (m) - sc-424105-NIC from Santa Cruz Biotechnology
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CSN3 Double Nickase Plasmid (m2) - sc-424105-NIC-2 from Santa Cruz Biotechnology
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CSN3 CRISPR Activation Plasmid (m) - sc-424105-ACT from Santa Cruz Biotechnology
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CSN3 CRISPR Activation Plasmid (m2) - sc-424105-ACT-2 from Santa Cruz Biotechnology
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CSN3 Lentiviral Activation Particles (m) - sc-424105-LAC from Santa Cruz Biotechnology
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CSN3 Lentiviral Activation Particles (m2) - sc-424105-LAC-2 from Santa Cruz Biotechnology
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CSN3 siRNA (m) - sc-60458 from Santa Cruz Biotechnology
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CSN3 shRNA Plasmid (m) - sc-60458-SH from Santa Cruz Biotechnology
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CSN3 shRNA (m) Lentiviral Particles - sc-60458-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN29085 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND29085 from Sigma-Aldrich
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COPS3 siRNA (Mouse) - CRM4779 from Cohesion Biosciences
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COPS3 - MBS8222161 from MyBioSource
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shRNA set against Mouse COPS3 (NM_011991.1) - SHH267809 from Creative biogene
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shRNA set against Mouse Cops3(NM_011991.1) - SHG192805 from Creative biogene
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Mouse COPS3 siRNA - orb284255 from Biorbyt
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COPS3 shRNA Plasmid (Mouse) - CHM4779 from Cohesion Biosciences
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COPS3 miRNA 3'UTR clone - MiUTR1M-03234 from Creative biogene
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